EC Number   |
Activating Compound |
Reference |
|---|
   2.7.11.15 | G protein betagamma-subunit |
- |
645028 |
| 2.7.11.15 | G protein betagamma-subunit |
10fold activation, beta-ARK 1 and 2, increases incorporation of phosphate from 4 to 10 mol phosphate/mol receptor |
645011 |
| 2.7.11.15 | G protein Gbetagamma subunits |
activate both ARK1 and ARK2 about 2.5fold |
645011 |
| 2.7.11.15 | PIP2 |
activates GRK2 through binding to its PH domain |
677232 |
| 2.7.11.15 | platelet-derived growth factor receptor-beta |
activates the enzyme by tyrosine phosphorylation at Y13, Y86, and Y92, required, the wild-type PDGFRbeta is 60fold more active with GRK2 than PDGFRbeta mutant Y857F, GRK2 activation also increases GRK2 degradation and downregulation, independent of Gbetagamma subunits and phosphoinositide 3-kinase |
662401 |
| 2.7.11.15 | G protein betagamma-subunit |
activates, binding domain is localized to the C-terminal region of beta-ARK |
645013, 645015, 645026 |
| 2.7.11.15 | cardiolipin |
activates, phosphorylation of beta2-AR |
645028 |
| 2.7.11.15 | phosphatidic acid |
activates, phosphorylation of beta2-AR |
645028 |
| 2.7.11.15 | phosphatidylglycerol |
activates, phosphorylation of beta2-AR |
645028 |
| 2.7.11.15 | phosphatidylserine |
activates, phosphorylation of beta2-AR |
645028 |
