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EC Number Activating Compound Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 2.3.2.23more 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) and O6-benzylguanine facilitate the ubiquitination and degradation of O6-methylguanine-DNA methyltransferase (MGMT) in several types of cancer cells involving the enzyme ubiquitin-conjugating enzyme E2 B. BCNU enhances the interaction between MGMT and UBE2B 758765
Display the word mapDisplay the reaction diagram Show all sequences 2.3.2.23more Derlin2 interacts with UBC6e in the complex involved in the regulation of ERAD enhancers. Derlin2 levels do not change in UBC6e-/- cells transduced with any of the UBC6e mutants, suggesting that it is not a substrate regulated by UBC6e, but is a member of a UBC6e complex 759764
Display the word mapDisplay the reaction diagram Show all sequences 2.3.2.23more the ubiquitin-like modifier-activating enzyme 1 (Uba1, EC 6.2.1.45) is a multidomain enzyme that serves as the gatekeeper of the ubiquitin (Ub) conjugation cascade by activating Ub in a two-step process involving adenylation and thioester bond formation followed by transfer of Ub to E2s in a process termed E1-E2 thioester transfer or transthiolation. Cdc34 is one of tens of E2s that must function with Uba1 despite significant differences at their predicted UFD-interacting surfaces. Molecular recognition of Cdc34 by Uba1, overview. Analysis with Uba1 from Homo sapiens, Saccharomyces cerevisiae, and Schizosaccharomyces pombe 759820
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