EC Number   |
Activating Compound |
Reference |
|---|
    2.1.1.13 | vitamin B12 |
2 to 14 fold stimulation after addition to media due to posttranscriptional regulation |
441212 |
| 2.1.1.13 | TrisHCl |
at 67 mM 1.2 fold activity |
441179 |
| 2.1.1.13 | K+ |
at 67 mM 1.4 fold activity |
441179 |
| 2.1.1.13 | Na+ |
at 67 mM 1.5 fold activity |
441179 |
| 2.1.1.13 | NH4+ |
at 67 mM 1.5 fold activity |
441179 |
| 2.1.1.13 | Li+ |
at 67 mM, 1.3fold activity |
441179 |
| 2.1.1.13 | S-adenosylmethionine |
at about 0.0001 mM |
441179 |
| 2.1.1.13 | NADPH |
reactivation of methionine synthase is dependent on NADPH concentration in a hyperbolic manner with maximum activity at about 0.2 mM |
703638 |
| 2.1.1.13 | S-adenosyl-L-methionine |
required |
659993 |
| 2.1.1.13 | methionine synthase reductase |
restores the activity of human methionine synthase through reductive methylation of methionine synthase-bound cob(II)alamin. Oxidized methionine synthase reductase does not reactivate methionine synthase, the presence of methionine synthase reductase along with AqCbl or MeCbl causes a dramatic increase in methionine synthase activity (7fold for AqCbl and 20fold for MeCbl) as compared to the cofactor alone |
703638 |
