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EC Number
Activating Compound
Commentary
Reference
1.1.1.42
acetic acid
mutant Y140T, 106fold activation compared to the wild-type enzyme
656180
1.1.1.42
ADP
-
656247
1.1.1.42
cis-aconitate
isozyme ICDH2, not isozyme ICDH1
656616
1.1.1.42
citrate
isozymes ICDH2 and ICDH1
656616
1.1.1.42
ethylamine
mutant K212Q, 4fold activation compared to the wild-type enzyme
656180
1.1.1.42
glutamate
-
654914
1.1.1.42
glutamate
160% stimulation of isozyme ICDH1 at 0.3 mM
656616
1.1.1.42
isocitrate
isozymes ICDH2 and ICDH1
656616
1.1.1.42
liposome
ICDH activity is enhanced with liposomes at 5 mol% cardiolipin, but inhibited at 30 mol% cardiolipin. 1,2-Dipalmitoyl-sn-glycero-3-phosphocholine liposomes did not affect the activity of ICDH
740946
1.1.1.42
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applied oxidative stress leads to upregulation of enzyme expression in erythrocytic stages
655456
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