EC Number   |
Activating Compound |
Reference  |
|---|
   2.7.7.6 | upstream binding factor |
UBF, activates rRNA gene transcription by several means, for example, by recruiting Pol I to the rDNA promoter, by stabilizing binding of TIF-IB/SL1, and by displacing nonspecific DNA binding proteins such as histone H1. And UBF has additional roles in regulation of Pol I promoter escape and transcription elongation |
701717 |
| 2.7.7.6 | TFIIIE |
a basal transcription factor, complexes with several ribosomal proteins and enhances tRNA and 5S rRNA transcription of the RNA polymerase, regualtion, overview |
702030 |
| 2.7.7.6 | glutamate |
glutamate remodels the sigma38 transcription complex for activation. Accumulation of the simple signaling molecule glutamate can reprogram RNA polymerase in vitro without the need for specific protein receptors. During osmotic activation, glutamate appears to act as a Hofmeister series osmolyte to facilitate promoter escape. Escape is accompanied by a remodeling of the key interaction between the sigma38 stress protein and the beta-flap of the bacterial core RNA polymerase. This activation event contrasts with the established mechanism of inhibition in which glutamate, by virtue of its electrostatic properties, helps to inhibit binding to ribosomal promoters after osmotic shock |
702224 |
| 2.7.7.6 | potassium acetate |
activates |
702224 |
| 2.7.7.6 | potassium aspartate |
activates |
702224 |
| 2.7.7.6 | potassium chloride |
activates |
702224 |
| 2.7.7.6 | potassium glutamate |
activates highly, role of potassium ion in the activation of osmotic transcription |
702224 |
| 2.7.7.6 | potassium nitrate |
activates |
702224 |
| 2.7.7.6 | TFB2 |
the essential initiation factor forms a network of interactions with DNA near the transcription start site and facilitates promoter melting but may not be essential for promoter recognition, TFB2 bridges upstream and downstream promoter contacts of the initiation complex, mapping of TFB2-DNA interactions at the transcription start site, overview |
703150 |
| 2.7.7.6 | more |
the archaeal Pol II-like transcription apparatus requires the general transcription factors TBP, TFB, TFE and TFS |
703354 |
