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EC Number Activating Compound Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.B41arachidonic acid - 757236
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.B41arotinoid acid i.e. TTNPB 757236
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.B41eicosatrienoic acid - 757236
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.B41L-NASPA - 757236
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.B41lysophosphatidic acid highly activating 757236
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.B41mead acid - 757236
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.B41more screening for SIRT6 activator small molecules, dose-response and Michaelis-Menten parameters of activation by the SIRT6 activators, overview. Structure-activity relationship analysis yields activators with improved potency and selectivity for SIRT6. Enzyme residue Arg65 is critical for activation by facilitating a conformational step that initiates chemical catalysis. Arg65 mediates a conformational change after substrate binding and that the rate of this change is enhanced by small-molecule activation of deacetylation and during demyristoylation 757236
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.B41N-linoleoylglycine - 757236
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.B41more binding of free fatty acids to SIRT6 significantly enhances SIRT6's in vitro histone deacetylase activity 757931
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.B41more binding of free fatty acids to SIRT6 significantly enhances SIRT6's in vitro histone deacetylase activity. Given Sirt6 critical roles in multiple molecular pathways, including DNA repair, telomere maintenance, glycolysis, gluconeogenesis, lipid metabolism, inflammation, and tumor suppression, it is clear that attempts to enhance the activity of SIRT6 could provide therapeutic benefits, development of SIRT6 activators, overview 757931
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