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Literature summary extracted from

  • Cui, L.; Yu, W.P.; DeAizpurua, H.J.; Schmidli, R.S.; Pallen, C.J.
    Cloning and characterization of islet cell antigen-related protein-tyrosine phosphatase (PTP), a novel receptor-like PTP and autoantigen in insulin-dependent diabetis (1996), J. Biol. Chem., 271, 24817-24823.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.3.48
-
 Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.1.3.48 C945S site-directed mutagenesis of the essential cysteine residue to a serine in the islet cell antigen-related PTP results in the expression of the intracellular region which does not catalyze hydrolysis of 4-nitrophenyl phosphate Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.48 H3VO4
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.48 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.3.48
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.48 4-nitrophenyl phosphate + H2O
-
 Homo sapiens 4-nitrophenol + phosphate
-
 ?
3.1.3.48 phosphotyrosyl-casein + H2O
-
 Homo sapiens ? + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.48 IAR
-
 Homo sapiens
3.1.3.48 islet cell antigen-related PTP
-
 Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.3.48 4.5
-
 islet cell antigen-related PTP Homo sapiens

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.1.3.48 4 4.5 islet cell antigen-related PTP Homo sapiens