Literature summary extracted from

Feingold K.R.; Wiley M.H.; Moser A.H.; Lear S.R.; Siperstein M.D.
Inhibition of HMG-CoA reductase by its substrates (1982), Biochem. Biophys. Res. Commun., 107, 1376-1383.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.1.3.47	hydroxymethylglutaryl-CoA	does not inhibit the reductase phosphatase itself but interacts with the reductase and prevents its activation	Rattus norvegicus
3.1.3.47	NADPH	does not inhibit the reductase phosphatase itself but interacts with the reductase and prevents its activation	Rattus norvegicus

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
3.1.3.47	microsome	-	Rattus norvegicus	-	-

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3.1.3.47	[hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate + H2O	Rattus norvegicus	-	?	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.1.3.47	Rattus norvegicus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.1.3.47	liver	-	Rattus norvegicus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.1.3.47	[hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate + H2O	-	Rattus norvegicus	[hydroxymethylglutaryl-CoA reductase (NADPH)] + phosphate	-	?
3.1.3.47	[hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate + H2O	-	Rattus norvegicus	?	-	?

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Release 2023.1 (January 2023)