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Literature summary extracted from

  • Huang, B.; Gudi, R.; Wu, P.; Harris, R.A.; Hamilton, J.; Popov, K.M.
    Isoenzymes of pyruvate dehydrogenase phosphatase. DNA-derived amino acid sequences, expression, and regulation (1998), J. Biol. Chem., 273, 17680-17688.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.3.43 spermine pyruvate dehydrogenase phosphatase 2 sensitive to Rattus norvegicus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.3.43 expression in Escherichia coli Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.3.43 mitochondrion
-
 Rattus norvegicus 5739
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.3.43 Ca2+ subunit pyruvate dehydrogenase phosphatase 1 regulated by Rattus norvegicus
3.1.3.43 Mg2+ sensivity of subunit pyruvate dehydrogenase phosphatase 1 10fold higher than of pyruvate dehydrogenase phosphatase 2 Rattus norvegicus
3.1.3.43 Mg2+ Km: 0.7 mM for pyruvate dehydrogenase phosphatase 1, Km: 17.4 mM for pyruvate dehydrogenase phosphatase 2 Rattus norvegicus
3.1.3.43 Mn2+ Km: 1.7 mM Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.43 [pyruvate dehydrogenase (lipoamide)]-phosphate + H2O Rattus norvegicus
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.43 Rattus norvegicus O88483
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.43 heart
-
 Rattus norvegicus
-
3.1.3.43 liver
-
 Rattus norvegicus
-
3.1.3.43 muscle skeletal Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.43 [pyruvate dehydrogenase (lipoamide)]-phosphate + H2O
-
 Rattus norvegicus [pyruvate dehydrogenase (lipoamide)] + phosphate
-
 ir
3.1.3.43 [pyruvate dehydrogenase (lipoamide)]-phosphate + H2O
-
 Rattus norvegicus ?
-
 ?