EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
1.2.4.4 | thiamine diphosphate | - |
Bos taurus | |
2.7.11.2 | 2-oxoisopentanoate | - |
Bos taurus | |
2.7.11.2 | acetyl-CoA | - |
Bos taurus | |
2.7.11.2 | NADH | activation, in the presence of NH4+ | Bos taurus | |
2.7.11.2 | NADH | activation, in the presence of K+ | Bos taurus | |
2.7.11.4 | histone H3 | 1.5 to 3fold | Oryctolagus cuniculus | |
2.7.11.4 | poly-L-arginine | 1.5 to 3fold | Oryctolagus cuniculus | |
2.7.11.4 | poly-L-lysine | 1.5 to 3fold | Oryctolagus cuniculus | |
2.7.11.4 | protamine | 1.5 to 3fold | Oryctolagus cuniculus | |
3.1.3.43 | NAD+ | reverses NADH inhibition | Bos taurus | |
3.1.3.43 | protamine | - |
Bos taurus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.2.1.104 | phosphorylation | - |
Bos taurus | |
2.7.11.2 | ADP | inhibition only in the presence of monovalent cations | Bos taurus | |
2.7.11.2 | Disulfides | thiols reverse | Bos taurus | |
2.7.11.2 | DTNB | - |
Bos taurus | |
2.7.11.2 | NEM | - |
Bos taurus | |
2.7.11.2 | pyruvate | - |
Bos taurus | |
2.7.11.4 | acyl-CoA | - |
Oryctolagus cuniculus | |
2.7.11.4 | ADP | 50% inhibition at 0.4 mM, inhibition can be reversed by 2 mM Mg2+ | Bos taurus | |
2.7.11.4 | ADP | 50% inhibition at 0.4 mM, inhibition can be reversed by 2 mM Mg2+ | Oryctolagus cuniculus | |
2.7.11.4 | ADP | 50% inhibition at 0.4 mM, inhibition can be reversed by 2 mM Mg2+ | Rattus norvegicus | |
2.7.11.4 | ATP | 50% inhibition at 0.2 mM, inhibition can be reversed by 2 mM Mg2+ | Oryctolagus cuniculus | |
2.7.11.4 | ATP | - |
Rattus norvegicus | |
2.7.11.4 | branched-chain 2-oxo acids | - |
Bos taurus | |
2.7.11.4 | branched-chain 2-oxo acids | - |
Oryctolagus cuniculus | |
2.7.11.4 | branched-chain 2-oxo acids | - |
Rattus norvegicus | |
2.7.11.4 | CDP | 50% inhibition at 0.4 mM, inhibition can be reversed by 2 mM Mg2+ | Oryctolagus cuniculus | |
2.7.11.4 | CoA | - |
Oryctolagus cuniculus | |
2.7.11.4 | CTP | 50% inhibition at 0.25 mM, inhibition can be reversed by 2 mM Mg2+ | Oryctolagus cuniculus | |
2.7.11.4 | GDP | 50% inhibition at 0.2 mM, inhibition can be reversed by 2 mM Mg2+ | Oryctolagus cuniculus | |
2.7.11.4 | GTP | 50% inhibition at 0.06 mM, inhibition can be reversed by 2 mM Mg2+ | Oryctolagus cuniculus | |
2.7.11.4 | heparin | 50% inhibition at 0.002 mM | Oryctolagus cuniculus | |
2.7.11.4 | additional information | no inhibition by coenzyme A; no inhibition by isovaleryl-CoA | Bos taurus | |
2.7.11.4 | additional information | no inhibition by isovaleryl-CoA | Oryctolagus cuniculus | |
2.7.11.4 | additional information | no inhibition by isovaleryl-CoA | Rattus norvegicus | |
2.7.11.4 | thiamine diphosphate | - |
Bos taurus | |
2.7.11.4 | thiamine diphosphate | - |
Oryctolagus cuniculus | |
2.7.11.4 | thiamine diphosphate | - |
Rattus norvegicus | |
2.7.11.4 | UDP | 50% inhibition at 0.25 mM, inhibition can be reversed by 2 mM Mg2+ | Oryctolagus cuniculus | |
2.7.11.4 | UTP | 50% inhibition at 0.1 mM, inhibition can be reversed by 2 mM Mg2+ | Oryctolagus cuniculus | |
3.1.3.43 | KCl | - |
Bos taurus | |
3.1.3.43 | NADH | - |
Bos taurus | |
3.1.3.43 | p-nitrophenylphosphate | - |
Bos taurus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.7.11.2 | 0.02 | - |
Mg2+ | - |
Bos taurus | |
3.1.3.43 | 0.0029 | - |
[Pyruvate dehydrogenase (lipoamide)]-phosphate | with Ca2+ | Bos taurus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.2.4.4 | mitochondrion | inner membrane matrix compartment | Bos taurus | 5739 | - |
2.7.11.2 | mitochondrion | inner membrane matrix compartment | Bos taurus | 5739 | - |
2.7.11.2 | mitochondrion | tightly bound to dihydrolipoamide acetyltransferase of pyruvate dehydrogenase complex | Bos taurus | 5739 | - |
2.7.11.4 | mitochondrion | - |
Rattus norvegicus | 5739 | - |
2.7.11.4 | mitochondrion | - |
Bos taurus | 5739 | - |
2.7.11.4 | mitochondrion | - |
Oryctolagus cuniculus | 5739 | - |
3.1.3.43 | mitochondrion | - |
Bos taurus | 5739 | - |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.2 | Mg2+ | requirement | Bos taurus | |
2.7.11.2 | Mn2+ | requirement | Bos taurus | |
2.7.11.2 | Mn2+ | can replace Mg2+ to some extent | Bos taurus | |
3.1.3.43 | Ca2+ | stimulates in presence of Mg2+ | Bos taurus | |
3.1.3.43 | Mg2+ | Km: 2 mM | Bos taurus | |
3.1.3.43 | Mn2+ | - |
Bos taurus |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
1.2.4.4 | additional information | - |
the MW of the multienzyme complex of bovine kidney is 3200000 Da | Bos taurus |
1.2.4.4 | additional information | - |
MW of the multienzyme complex of bovine heart is 8500000 Da | Bos taurus |
1.2.4.4 | 35000 | - |
alpha2,beta2, 2 * 46000 + 2 * 35000, enzyme from kidney, SDS-PAGE | Bos taurus |
1.2.4.4 | 36000 | - |
alpha2,beta2, 2 * 41000 + 2 * 36000, heart enzyme, SDS-PAGE | Bos taurus |
1.2.4.4 | 41000 | - |
alpha2,beta2, 2 * 41000 + 2 * 36000, heart enzyme, SDS-PAGE | Bos taurus |
1.2.4.4 | 46000 | - |
alpha2,beta2, 2 * 46000 + 2 * 35000, enzyme from kidney, SDS-PAGE | Bos taurus |
1.2.4.4 | 154000 | - |
E1, heart | Bos taurus |
2.7.11.2 | 45000 | - |
1 * 48000, alpha + 1 * 45000, beta, SDS-PAGE | Bos taurus |
2.7.11.2 | 48000 | - |
1 * 48000, alpha + 1 * 45000, beta, SDS-PAGE | Bos taurus |
2.7.11.2 | 100000 | - |
- |
Bos taurus |
2.7.11.4 | 460000 | - |
gel filtration | Oryctolagus cuniculus |
3.1.3.43 | 150000 | - |
- |
Bos taurus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.2.4.4 | additional information | Bos taurus | regulation of the enzyme complex by phosphorylation and dephosphorylation | ? | - |
? | |
2.7.11.2 | ATP + [pyruvate dehydrogenase (lipoamide)] | Bos taurus | catalyzes inactivation through phosphorylation of pyruvate dehydrogenase complex EC 1.2.4.1 | ADP + [pyruvate dehydrogenase (lipoamide)] phosphate | - |
ir | |
2.7.11.4 | ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] | Rattus norvegicus | phosphorylation inactivates EC 1.2.4.4 | ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate | - |
? | |
2.7.11.4 | ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] | Bos taurus | phosphorylation inactivates EC 1.2.4.4 | ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate | - |
? | |
2.7.11.4 | ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] | Oryctolagus cuniculus | phosphorylation inactivates EC 1.2.4.4 | ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate | - |
? | |
3.1.3.43 | [pyruvate dehydrogenase (lipoamide)]-phosphate + H2O | Bos taurus | - |
? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.2.1.104 | Bos taurus | - |
- |
- |
1.2.4.4 | Bos taurus | - |
- |
- |
2.7.11.2 | Bos taurus | - |
- |
- |
2.7.11.4 | Bos taurus | - |
- |
- |
2.7.11.4 | Oryctolagus cuniculus | - |
- |
- |
2.7.11.4 | Rattus norvegicus | - |
- |
- |
3.1.3.43 | Bos taurus | - |
overview | - |
EC Number | Posttranslational Modification | Comment | Organism |
---|---|---|---|
1.2.1.104 | side-chain modification | - |
Bos taurus |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.7.11.2 | kidney, from highly purifed pyruvate dehydrogenase-complex | Bos taurus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.2.4.4 | heart | - |
Bos taurus | - |
1.2.4.4 | kidney | - |
Bos taurus | - |
2.7.11.2 | heart | - |
Bos taurus | - |
2.7.11.2 | kidney | - |
Bos taurus | - |
2.7.11.4 | kidney | - |
Rattus norvegicus | - |
2.7.11.4 | kidney | - |
Bos taurus | - |
2.7.11.4 | kidney | - |
Oryctolagus cuniculus | - |
3.1.3.43 | heart | - |
Bos taurus | - |
3.1.3.43 | kidney | - |
Bos taurus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.2.4.4 | additional information | regulation of the enzyme complex by phosphorylation and dephosphorylation | Bos taurus | ? | - |
? | |
2.7.11.2 | ATP + [pyruvate dehydrogenase (lipoamide)] | highly specific for the substrate | Bos taurus | ADP + [pyruvate dehydrogenase (lipoamide)] phosphate | - |
ir | |
2.7.11.2 | ATP + [pyruvate dehydrogenase (lipoamide)] | phosphorylation sites are 3 Ser-residues in the alpha-subunit, i.e. E1, MW 41000, of pyruvate dehydrogenase | Bos taurus | ADP + [pyruvate dehydrogenase (lipoamide)] phosphate | - |
ir | |
2.7.11.2 | ATP + [pyruvate dehydrogenase (lipoamide)] | catalyzes inactivation through phosphorylation of pyruvate dehydrogenase complex EC 1.2.4.1 | Bos taurus | ADP + [pyruvate dehydrogenase (lipoamide)] phosphate | - |
ir | |
2.7.11.2 | additional information | no activity with glycogen synthase a and rabbit skeletal muscle phosphorylase b | Bos taurus | ? | - |
? | |
2.7.11.4 | ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] | 2 Ser-residues in E1-alpha-subunit | Rattus norvegicus | ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate | - |
? | |
2.7.11.4 | ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] | 2 Ser-residues in E1-alpha-subunit | Bos taurus | ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate | - |
? | |
2.7.11.4 | ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] | 2 Ser-residues in E1-alpha-subunit | Oryctolagus cuniculus | ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate | - |
? | |
2.7.11.4 | ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] | phosphorylation inactivates EC 1.2.4.4 | Rattus norvegicus | ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate | - |
? | |
2.7.11.4 | ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] | phosphorylation inactivates EC 1.2.4.4 | Bos taurus | ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate | - |
? | |
2.7.11.4 | ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] | phosphorylation inactivates EC 1.2.4.4 | Oryctolagus cuniculus | ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate | - |
? | |
3.1.3.43 | [pyruvate dehydrogenase (lipoamide)]-phosphate + H2O | - |
Bos taurus | [pyruvate dehydrogenase (lipoamide)] + phosphate | - |
ir | |
3.1.3.43 | [pyruvate dehydrogenase (lipoamide)]-phosphate + H2O | - |
Bos taurus | ? | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
1.2.4.4 | More | the multienzyme complex from bovine heart contains 4 times E1, 60 times E2 and 2 times E3 | Bos taurus |
1.2.4.4 | tetramer | alpha2,beta2, 2 * 46000 + 2 * 35000, enzyme from kidney, SDS-PAGE | Bos taurus |
1.2.4.4 | tetramer | alpha2,beta2, 2 * 41000 + 2 * 36000, heart enzyme, SDS-PAGE | Bos taurus |
2.7.11.2 | dimer | 1 * 48000, alpha + 1 * 45000, beta, SDS-PAGE | Bos taurus |
2.7.11.2 | More | kinase activity resides in alpha-subunit | Bos taurus |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.7.11.2 | 0.533 | - |
ATP | - |
Bos taurus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.2.4.4 | CoA | - |
Bos taurus | |
1.2.4.4 | NAD+ | - |
Bos taurus | |
2.7.11.2 | ATP | dependent on | Bos taurus |