Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Malfroy, B.; Schwartz, J.C.
    Properties of enkephalinase from rat kidney: comparison of dipeptidyl-carboxypeptidase and endopeptidase activities (1982), Biochem. Biophys. Res. Commun., 106, 276-285.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.11 EDTA
-
 Mus musculus
3.4.24.11 EDTA
-
 Rattus norvegicus
3.4.24.11 phosphoramidon
-
 Mus musculus
3.4.24.11 phosphoramidon
-
 Rattus norvegicus
3.4.24.11 thiorphan
-
 Mus musculus
3.4.24.11 thiorphan
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.24.11 0.008
-
 Tyr-Gly-Gly-Phe-Met
-
 Rattus norvegicus
3.4.24.11 0.013
-
 Tyr-D-Ala-Gly-Phe-Met
-
 Rattus norvegicus
3.4.24.11 0.018
-
 Tyr-D-Ala-Gly-Phe-Leu
-
 Rattus norvegicus
3.4.24.11 0.019
-
 Tyr-D-Ala-Gly-Phe-Leu
-
 Mus musculus
3.4.24.11 0.061
-
 Tyr-D-Ala-Gly-Phe-met-NH2
-
 Rattus norvegicus
3.4.24.11 0.072
-
 Tyr-D-Ala-Gly-Phe-met-NH2
-
 Mus musculus
3.4.24.11 0.32
-
 Tyr-D-Ala-Gly-Phe-met-NH2
-
 Rattus norvegicus
3.4.24.11 0.35
-
 hippuryl-Arg-Arg-Leu-2-naphthylamide
-
 Rattus norvegicus
3.4.24.11 0.38
-
 hippuryl-Arg-Arg-Ala-2-naphthylamide
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.11 membrane bound Rattus norvegicus 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.24.11 additional information metalloproteinase Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.11 Mus musculus
-
-
-
3.4.24.11 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.11 corpus striatum
-
 Mus musculus
-
3.4.24.11 kidney
-
 Mus musculus
-
3.4.24.11 kidney
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.11 D-Ala2-Leu5-enkephalin + H2O i.e. Tyr-D-Ala-Gly-Phe-Leu Mus musculus Tyr-D-Ala-Gly + Phe-Leu
-
 ?
3.4.24.11 D-Ala2-Leu5-enkephalin + H2O i.e. Tyr-D-Ala-Gly-Phe-Leu Rattus norvegicus Tyr-D-Ala-Gly + Phe-Leu
-
 ?
3.4.24.11 enkephalin + H2O hydrolysis at Gly3-Phe4 Rattus norvegicus ?
-
 ?
3.4.24.11 hippuryl-Arg-Arg-Ala-2-naphthylamide + H2O
-
 Rattus norvegicus hippuryl-Arg-Arg + Ala-2-naphthylamide
-
 ?
3.4.24.11 hippuryl-Arg-Arg-Leu-2-naphthylamide + H2O
-
 Rattus norvegicus hippuryl-Arg-Arg + Leu-2-naphthylamide
-
 ?
3.4.24.11 Tyr-D-Ala-Gly-Phe-Met + H2O
-
 Rattus norvegicus Tyr-D-Ala-Gly + Phe-Met
-
 ?
3.4.24.11 Tyr-D-Ala-Gly-Phe-Met-NH2 + H2O
-
 Mus musculus Tyr-D-Ala-Gly + Phe-Met-NH2
-
 ?
3.4.24.11 Tyr-D-Ala-Gly-Phe-Met-NH2 + H2O
-
 Rattus norvegicus Tyr-D-Ala-Gly + Phe-Met-NH2
-
 ?
3.4.24.11 Tyr-Gly-Gly-Phe-Met + H2O i.e. methionine enkephalin Rattus norvegicus Tyr-Gly-Gly + Phe-Met
-
 ?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.4.24.11 6.83
-
 hippuryl-Arg-Arg-Ala-2-naphthylamide
-
 Rattus norvegicus
3.4.24.11 17.4
-
 Tyr-D-Ala-Gly-Phe-Met
-
 Rattus norvegicus
3.4.24.11 21.1
-
 Tyr-Gly-Gly-Phe-Met
-
 Rattus norvegicus
3.4.24.11 42
-
 Tyr-D-Ala-Gly-Phe-met-NH2
-
 Rattus norvegicus
3.4.24.11 72
-
 hippuryl-Arg-Arg-Leu-2-naphthylamide
-
 Rattus norvegicus