Any feedback?
Literature summary extracted from
- Degradation of human gastrin and CCK by endopeptidase 24.11: differential behaviour of the sulphated and unsulphated peptides (1989), Biochim. Biophys. Acta, 996, 82-88.
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.4.24.11 | 0.033 | - |
unsulfated cholecystokinin octapeptide | - |
Homo sapiens |  |
| 3.4.24.11 | 0.049 | - |
gastrin G-17 | sulfated | Homo sapiens | |
| 3.4.24.11 | 0.057 | - |
sulfated cholecystokinin octapeptide | - |
Homo sapiens | |
| 3.4.24.11 | 0.068 | - |
gastrin G-17 | unsulfated | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.24.11 | additional information | Homo sapiens | the enzyme is responsible for the difference in metabolism of sulfated and unsulfated gastrin in human circulation | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.24.11 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.24.11 | kidney | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.24.11 | Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-PheNH2 + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.24.11 | cholecystokinin-8 + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.24.11 | gastrin G-17 + H2O | cleavage at four sites, Trp4-Leu5, Ala11-Tyr12, Gly13-Trp14 and Asp16-Phe17 | Homo sapiens | ? | - |
? | |
| 3.4.24.11 | gastrin G-17 + H2O | sulfated and unsulfated gastrin, cleavage is faster with the sulfated peptide | Homo sapiens | ? | - |
? | |
| 3.4.24.11 | additional information | the enzyme is responsible for the difference in metabolism of sulfated and unsulfated gastrin in human circulation | Homo sapiens | ? | - |
? | |
| 3.4.24.11 | sulfated cholecystokinin octapeptide + H2O | - |
Homo sapiens | ? | - |
? | |
Turnover Number [1/s]
| EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.4.24.11 | 0.767 | - |
gastrin G-17 | sulfated | Homo sapiens | |
| 3.4.24.11 | 1.07 | - |
gastrin G-17 | unsulfated | Homo sapiens | |
| 3.4.24.11 | 24.6 | - |
unsulfated cholecystokinin octapeptide | - |
Homo sapiens | |
| 3.4.24.11 | 31.1 | - |
sulfated cholecystokinin octapeptide | - |
Homo sapiens | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
