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Literature summary extracted from

  • Kerr, M.A.
    The human complement system: assembly of the classical pathway C3 convertase (1980), Biochem. J., 189, 173-181.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.21.43 complement component C2b essential for the interaction of C4b and C2a Homo sapiens

General Stability

EC Number General Stability Organism
3.4.21.43 complex C4bC2a extremely unstable Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.43 diisopropyl fluorophosphate
-
 Homo sapiens
3.4.21.43 EDTA inhibits interaction between C4b and C2b Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.43 membrane
-
 Homo sapiens 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.21.43 Ca2+ formation of the bimolecular complex C4b2a, i.e. C3 convertase Homo sapiens
3.4.21.43 Iodine stabilization Homo sapiens
3.4.21.43 Mg2+ formation of the bimolecular complex C4b2a, i.e. C3 convertase Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.21.43 305000
-
 calculation from sedimentation coefficient and diffusion constant Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.43 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.21.43
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.43 plasma
-
 Homo sapiens
-

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.21.43 37
-
-
 Homo sapiens

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
3.4.21.43 37
-
 decay rate constant k: 2.0 per min Homo sapiens