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Literature summary extracted from
- Purification of human serum angiotensin I-converting enzyme by affinity chromatography (1981), Anal. Biochem., 111, 227-234.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.15.1 | captopril | i.e. SQ 14225 | Homo sapiens |  |
| 3.4.15.1 | D-Cys-L-Pro | competitive to hippuryl-His-Leu | Homo sapiens | |
| 3.4.15.1 | EDTA | - |
Homo sapiens | |
| 3.4.15.1 | L-Cys-L-Pro | - |
Homo sapiens | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.4.15.1 | 0.071 | - |
angiotensin I | - |
Homo sapiens | |
| 3.4.15.1 | 1 | - |
hippuryl-His-Leu | Tris-NaCl buffer | Homo sapiens | |
| 3.4.15.1 | 3 | - |
hippuryl-His-Leu | phosphosaline buffer | Homo sapiens | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.4.15.1 | 145000 | - |
1 * 145000, enzyme in reduced and unreduced samples, SDS-PAGE | Homo sapiens |
| 3.4.15.1 | 155000 | - |
sucrose density gradient ultracentrifugation | Homo sapiens |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.15.1 | Homo sapiens | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.4.15.1 | - |
Homo sapiens |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.15.1 | serum | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 3.4.15.1 | additional information | - |
- |
Homo sapiens |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.15.1 | angiotensin I + H2O | - |
Homo sapiens | angiotensin II + His-Leu | - |
? | |
| 3.4.15.1 | bradykinin + H2O | - |
Homo sapiens | Phe-Arg + Ser-Pro + Arg-Pro-Pro-Gly-Phe | - |
? | |
| 3.4.15.1 | hippuryl-His-Leu + H2O | - |
Homo sapiens | hippuric acid + His-Leu | - |
? | |
| 3.4.15.1 | p-nitrobenzyloxycarbonyl-Gly-Gly-Gly + H2O | - |
Homo sapiens | ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.4.15.1 | monomer | 1 * 145000, enzyme in reduced and unreduced samples, SDS-PAGE | Homo sapiens |
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