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Literature summary extracted from

  • Tsaoussis, V.; Vakirtzi-Lemonias, C.
    The mouse plasma PAF acetylhydrolase: I. Characterization and properties (1994), J. Lipid Mediat. Cell Signal., 9, 301-315.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.1.47 deoxycholate activation Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.47 1-O-hexadecyl-2-acetyl-rac-glycerol
-
 Mus musculus
3.1.1.47 1-O-hexadecyl-2-N-methylcarbamoyl-sn-glycero-3-phospho(N,N,N-trimethyl)hexanolamine
-
 Mus musculus
3.1.1.47 1-O-hexadecyl-2-N-methylcarbamoyl-sn-glycero-3-phosphocholine
-
 Mus musculus
3.1.1.47 1-O-hexadecyl-2-O-methyl-sn-glycero-3-phosphocholine
-
 Mus musculus
3.1.1.47 1-O-hexadecyl-2-thioacetyl-sn-glycero-3-phosphocholine
-
 Mus musculus
3.1.1.47 1-oleyl-2-acetyl-sn-glycerol
-
 Mus musculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.1.47 0.0074
-
 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine
-
 Mus musculus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.1.47 additional information no stimulation by Ca2+ or Mg2+ Mus musculus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.1.47 46000
-
 x * 46000 + x * 63000, SDS-PAGE Mus musculus
3.1.1.47 63000
-
 x * 46000 + x * 63000, SDS-PAGE Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.47 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O Mus musculus the substrate is a potent lipid mediator, involved in pathological responses, particularly in inflammation and allergy. Its level is regulated by hydrolysis ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.47 Mus musculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.1.47
-
 Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.47 plasma
-
 Mus musculus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.1.47 0.038
-
-
 Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.47 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O i.e. PAF Mus musculus 1-O-alkyl-sn-glycero-3-phosphocholine + acetate
-
 ?
3.1.1.47 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O the substrate is a potent lipid mediator, involved in pathological responses, particularly in inflammation and allergy. Its level is regulated by hydrolysis Mus musculus ?
-
 ?
3.1.1.47 1-O-hexadecyl-2-N-methylcarbamoyl-sn-glycero-3-phospho(N,N,N-trimethyl)hexanolamine
-
 Mus musculus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.1.47 ? x * 46000 + x * 63000, SDS-PAGE Mus musculus