Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Mok, J.W.; Choi, K.W.
    Novel function of N-acetyltransferase for microtubule stability and JNK signaling in Drosophila organ development (2021), Proc. Natl. Acad. Sci. USA, 118, e2010140118 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.308 expressed in Escherichia coli Rosetta(DE3) cells Drosophila melanogaster

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.308 microtubule
-
 Drosophila melanogaster 5874
-

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.308 Drosophila melanogaster
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.308 Sepharose column chromatography and amylose Sepharose resin column chromatography Drosophila melanogaster

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.308 acetyl-CoA + an N-terminal-L-methionyl-[alpha-tubulin]
-
 Drosophila melanogaster an N-terminal-Nalpha-acetyl-L-methionyl-[alpha-tubulin] + CoA
-
 ?
2.3.1.308 acetyl-CoA + an N-terminal-L-methionyl-[beta-tubulin]
-
 Drosophila melanogaster an N-terminal-Nalpha-acetyl-L-methionyl-[beta-tubulin] + CoA
-
 ?
2.3.1.308 additional information alphabeta-tubulin dimers are not acetylated by the enzyme Drosophila melanogaster ?
-
-

Subunits

EC Number Subunits Comment Organism
2.3.1.308 ? x * 55000, GST-tagged enzyme, SDS-PAGE Drosophila melanogaster

Synonyms

EC Number Synonyms Comment Organism
2.3.1.308 CG11539
-
 Drosophila melanogaster
2.3.1.308 microtubule-associated Nat9
-
 Drosophila melanogaster
2.3.1.308 Mnat9
-
 Drosophila melanogaster

General Information

EC Number General Information Comment Organism
2.3.1.308 malfunction enzyme loss of causes severe developmental defects in multiple tissues. Enzyme loss results in various spindle defects during mitosis in the syncytial embryo. Knockdown of enzyme causes apoptotic cell death in the wing disc Drosophila melanogaster
2.3.1.308 physiological function the enzyme regulates cell signaling and microtubule stability. The enzyme is required for regulation of c-Jun N-terminal kinase signaling to promote cell survival in developing Drosophila organs Drosophila melanogaster