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Literature summary extracted from

  • Park, N.Y.; Im, S.; Jiang, Q.
    Different forms of vitamin E and metabolite 13-carboxychromanols inhibit cyclooxygenase-1 and its catalyzed thromboxane in platelets, and tocotrienols and 13-carboxychromanols are competitive inhibitors of 5-lipoxygenase (2022), J. Nutr. Biochem., 100, 108884 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.34 delta-tocopherol-13'-carboxychromanol competitive, compound decreases leukotriene B4 from stimulated neutrophil-like cells without affecting translocation of 5-Lox from cytosol to the nucleus. Compound additionally inhibits cyclooxygenases Cox-1 and Cox-2 Homo sapiens
1.13.11.34 delta-tocotrienol competitive, compound decreases leukotriene B4 from stimulated neutrophil-like cells without affecting translocation of 5-Lox from cytosol to the nucleus. Compound additionally inhibits cyclooxygenases Cox-1 and Cox-2 Homo sapiens
1.13.11.34 delta-tocotrienol-13'-carboxychromanol competitive, compound decreases leukotriene B4 from stimulated neutrophil-like cells without affecting translocation of 5-Lox from cytosol to the nucleus. Compound additionally inhibits cyclooxygenases Cox-1 and Cox-2 Homo sapiens
1.14.99.1 delta-tocopherol-13'-carboxychromanol inhibits isoform Cox-1 and suppresses Cox-1 mediated formation of thromboxane in collagen-stimulated rat's platelets Homo sapiens
1.14.99.1 delta-tocotrienol inhibits isoform Cox-1 and suppresses Cox-1 mediated formation of thromboxane in collagen-stimulated rat's platelets Homo sapiens
1.14.99.1 delta-tocotrienol-13'-carboxychromanol inhibits isoform Cox-1 and suppresses Cox-1 mediated formation of thromboxane in collagen-stimulated rat's platelets Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.34 Homo sapiens P09917
-
-
1.14.99.1 Homo sapiens
-
-
-

Synonyms

EC Number Synonyms Comment Organism
1.13.11.34 5-LOX
-
 Homo sapiens
1.13.11.34 ALOX5
-
 Homo sapiens
1.14.99.1 COX-1
-
 Homo sapiens
1.14.99.1 COX-2
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.13.11.34 0.0008
-
 delta-tocotrienol-13'-carboxychromanol pH not specified in the publication, temperature not specified in the publication Homo sapiens
1.13.11.34 0.0016
-
 delta-tocopherol-13'-carboxychromanol pH not specified in the publication, temperature not specified in the publication Homo sapiens
1.13.11.34 0.0022
-
 delta-tocotrienol pH not specified in the publication, temperature not specified in the publication Homo sapiens