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Literature summary extracted from
- Cloning and characterization the nicotine degradation enzymes 6-hydroxypseudooxynicotine amine oxidase and 6-hydroxy-3-succinoylpyridine hydroxylase in Pseudomonas geniculata N1 (2019), Int. Biodeter. Biodegrad., 142, 83-90 .
No PubMed abstract available
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.13.163 | Cd2+ | strong inhibition | Stenotrophomonas geniculata |  |
| 1.14.13.163 | Zn2+ | strong inhibition | Stenotrophomonas geniculata | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.14.13.163 | 0.0359 | - |
4-(6-hydroxypyridin-3-yl)-4-oxobutanoate | pH 8, 25°C | Stenotrophomonas geniculata | |
| 1.14.13.163 | 0.0756 | - |
NADH | pH 8, 25°C | Stenotrophomonas geniculata | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.13.163 | Stenotrophomonas geniculata | A0A0L8AFM7 | - |
- |
| 1.14.13.163 | Stenotrophomonas geniculata N1 | A0A0L8AFM7 | - |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.13.163 | 4-(6-hydroxypyridin-3-yl)-4-oxobutanoate + 2 NADH + 2 H+ + O2 | - |
Stenotrophomonas geniculata | 2,5-dihydroxypyridine + succinate semialdehyde + 2 NAD+ + H2O | - |
? | |
| 1.14.13.163 | 4-(6-hydroxypyridin-3-yl)-4-oxobutanoate + 2 NADH + 2 H+ + O2 | - |
Stenotrophomonas geniculata N1 | 2,5-dihydroxypyridine + succinate semialdehyde + 2 NAD+ + H2O | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.13.163 | HSP monooxygenase | - |
Stenotrophomonas geniculata |
| 1.14.13.163 | W7K_00670 | - |
Stenotrophomonas geniculata |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.14.13.163 | 20 | - |
- |
Stenotrophomonas geniculata |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.14.13.163 | 8.5 | - |
- |
Stenotrophomonas geniculata |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.13.163 | FAD | sequence contains a FAD-binding domain | Stenotrophomonas geniculata | |
Expression
| EC Number | Organism | Comment | Expression |
|---|---|---|---|
| 1.14.13.163 | Stenotrophomonas geniculata | expression is significantly upregulated in response to nicotine | up |
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