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Literature summary extracted from

  • Thiel, D.; Blume, F.; Jaeger, C.; Deska, J.
    Chloroperoxidase-Catalyzed Achmatowicz Rearrangements (2018), Eur. J. Org. Chem., 2018, 2717-2725 .
No PubMed abstract available

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.11.1.10 RH + chloride + H2O2 Leptoxyphium fumago
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 RCl + 2 H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.11.1.10 Leptoxyphium fumago P04963 Caldariomyces fumago
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.11.1.10 additional information chloroperoxidase from Caldariomyces fumago catalyzes the selective oxidation of furfuryl alcohols in an Achmatowicz-type ring expansion. In combination with glucose oxidase as oxygen-activating biocatalyst, a purely enzymatic, aerobic protocol for the synthesis of 6-hydroxypyranone building blocks is obtained. Thanks to an only modest stereochemical bias of the oxygenating heme protein, optically active alcohols of either configuration are converted without a significant mismatch opening up opportunities for enantioselective multienzymatic cascades. Balancing the oxidase-driven aerobic activation, extended enzyme half-lives and productive conversion of poorly soluble and slowly reacting substrates can be achieved with high yields of the six-membered O-heterocycles. The chloroperoxidase from Caldariomyces fumago (CPO) acts as peroxidase-P450 functional hybrid. Enantiodiscrimination in the oxidative conversion of racemic furfuryl alcohols by enzyme CPO in a coupled assay with the glucose oxidase (GOx) from Aspergillus niger, substrate specificity, overview Leptoxyphium fumago ?
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1.11.1.10 RH + chloride + H2O2
-
 Leptoxyphium fumago RCl + 2 H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.11.1.10 chloroperoxidase
-
 Leptoxyphium fumago
1.11.1.10 CPO
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 Leptoxyphium fumago

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.11.1.10 30 40 assay at Leptoxyphium fumago

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.11.1.10 4.5 7 assay at Leptoxyphium fumago

Cofactor

EC Number Cofactor Comment Organism Structure
1.11.1.10 heme
-
 Leptoxyphium fumago