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Literature summary extracted from
- An investigation of the monoamine oxidase inhibition properties of pyrrolo[3,4-f]indole-5,7-dione and indole-5,6-dicarbonitrile derivatives (2018), Drug Dev. Res., 79, 81-93 .
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 1.4.3.4 | drug development | active monoamine oxidase inhibitors represent suitable leads for the development of drugs for neurodegenerative and neuropsychiatric disorders such as Parkinson's disease and depression. Monoamine oxidase inhibitors are also of interest for the treatment of prostate cancer, certain types of cardiomyopathies and Alzheimer's disease | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.4.3.4 | (2E)-3-chloro-2-(6-nitro-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)-3-(thiophen-2-yl)prop-2-enal | - |
Homo sapiens | |
| 1.4.3.4 | (2E)-3-chloro-2-(6-nitro-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)-3-phenylprop-2-enal | - |
Homo sapiens | |
| 1.4.3.4 | (2E)-3-chloro-3-(4-methylphenyl)-2-(6-nitro-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)prop-2-enal | - |
Homo sapiens | |
| 1.4.3.4 | 1-hydroxy-2-(4-methoxyphenyl)-2,3-dihydropyrrolo[3,4-f]indole-5,7(1H,6H)-dione | - |
Homo sapiens | |
| 1.4.3.4 | 1-hydroxy-2-(4-methylphenyl)-3-propanoyl-1H-indole-5,6-dicarbonitrile | - |
Homo sapiens | |
| 1.4.3.4 | 1-hydroxy-3-(4-methoxybenzoyl)-1H-indole-5,6-dicarboxylic acid | - |
Homo sapiens | |
| 1.4.3.4 | 1-hydroxy-3-(4-methoxybenzoyl)pyrrolo[3,4-f]indole-5,7(1H,6H)-dione | - |
Homo sapiens | |
| 1.4.3.4 | 1-hydroxy-3-(4-methylbenzoyl)pyrrolo[3,4-f]indole-5,7(1H,6H)-dione | - |
Homo sapiens | |
| 1.4.3.4 | 1-hydroxy-3-propanoyl-2-(thiophen-2-yl)-1H-indole-5,6-dicarbonitrile | - |
Homo sapiens | |
| 1.4.3.4 | 1-methoxy-2-(4-methoxyphenyl)-5,7-dioxo-1,2,3,5,6,7-hexahydropyrrolo[3,4-f]indole-3-carbaldehyde | - |
Homo sapiens | |
| 1.4.3.4 | 1-methoxy-2-(4-methylphenyl)-5,7-dioxo-1,2,3,5,6,7-hexahydropyrrolo[3,4-f]indole-3-carbaldehyde | - |
Homo sapiens | |
| 1.4.3.4 | 1-methoxy-5,7-dioxo-2-(thiophen-2-yl)-1,2,3,5,6,7-hexahydropyrrolo[3,4-f]indole-3-carbaldehyde | - |
Homo sapiens | |
| 1.4.3.4 | 1-methoxy-5,7-dioxo-2-phenyl-1,2,3,5,6,7-hexahydropyrrolo[3,4-f]indole-3-carbaldehyde | - |
Homo sapiens | |
| 1.4.3.4 | 2-(4-methylphenyl)-3-propanoyl-1-(propanoyloxy)-1H-indole-5,6-dicarbonitrile | - |
Homo sapiens | |
| 1.4.3.4 | 3-(4-methoxybenzoyl)-1H-indole-5,6-dicarbonitrile | - |
Homo sapiens | |
| 1.4.3.4 | 3-acetyl-1-(acetyloxy)-2-(4-methoxyphenyl)-1H-indole-5,6-dicarbonitrile | - |
Homo sapiens | |
| 1.4.3.4 | 3-acetyl-1-(acetyloxy)-2-(thiophen-2-yl)-1H-indole-5,6-dicarbonitrile | - |
Homo sapiens | |
| 1.4.3.4 | 3-acetyl-1-(acetyloxy)-2-phenyl-1H-indole-5,6-dicarbonitrile | - |
Homo sapiens | |
| 1.4.3.4 | 3-acetyl-1-hydroxy-2-(4-methoxyphenyl)-1H-indole-5,6-dicarbonitrile | - |
Homo sapiens | |
| 1.4.3.4 | 3-acetyl-1-hydroxy-2-(4-methylphenyl)-1H-indole-5,6-dicarbonitrile | - |
Homo sapiens | |
| 1.4.3.4 | 3-acetyl-1-hydroxy-2-(thiophen-2-yl)-1H-indole-5,6-dicarbonitrile | - |
Homo sapiens | |
| 1.4.3.4 | 3-acetyl-1-hydroxy-2-phenyl-1H-indole-5,6-dicarbonitrile | - |
Homo sapiens | |
| 1.4.3.4 | 3-benzoyl-1-hydroxy-1H-indole-5,6-dicarboxylic acid | - |
Homo sapiens | |
| 1.4.3.4 | 3-benzoyl-1-hydroxypyrrolo[3,4-f]indole-5,7(1H,6H)-dione | - |
Homo sapiens | |
| 1.4.3.4 | 3-bromo-1-hydroxy-2-(4-methoxyphenyl)-2,3-dihydropyrrolo[3,4-f]indole-5,7(1H,6H)-dione | - |
Homo sapiens | |
| 1.4.3.4 | 3-bromo-1-hydroxy-2-(4-methylphenyl)-2,3-dihydropyrrolo[3,4-f]indole-5,7(1H,6H)-dione | - |
Homo sapiens | |
| 1.4.3.4 | 3-bromo-1-hydroxy-2-phenyl-2,3-dihydropyrrolo[3,4-f]indole-5,7(1H,6H)-dione | - |
Homo sapiens | |
| 1.4.3.4 | 3-bromo-1-methoxy-2-(4-methoxyphenyl)-2,3-dihydropyrrolo[3,4-f]indole-5,7(1H,6H)-dione | - |
Homo sapiens | |
| 1.4.3.4 | 3-bromo-1-methoxy-6-methyl-2-(4-methylphenyl)-2,3-dihydropyrrolo[3,4-f]indole-5,7(1H,6H)-dione | - |
Homo sapiens | |
| 1.4.3.4 | 3-butanoyl-1-(butanoyloxy)-2-(4-methylphenyl)-1H-indole-5,6-dicarbonitrile | - |
Homo sapiens | |
| 1.4.3.4 | 3-butanoyl-1-(butanoyloxy)-2-(thiophen-2-yl)-1H-indole-5,6-dicarbonitrile | - |
Homo sapiens | |
| 1.4.3.4 | lazabemide | - |
Homo sapiens |  |
| 1.4.3.4 | safinamide | - |
Homo sapiens | |
| 1.4.3.4 | toloxatone | - |
Homo sapiens | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.4.3.4 | Homo sapiens | P21397 | - |
- |
| 1.4.3.4 | Homo sapiens | P27338 | - |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.4.3.4 | kynuramine + H2O + O2 | - |
Homo sapiens | 4-hydroxyquinoline + NH3 + H2O2 | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.4.3.4 | MAO-A | - |
Homo sapiens |
| 1.4.3.4 | MAO-B | - |
Homo sapiens |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 1.4.3.4 | 0.000023 | - |
pH 7.4, 37°C | Homo sapiens | 3-bromo-1-methoxy-6-methyl-2-(4-methylphenyl)-2,3-dihydropyrrolo[3,4-f]indole-5,7(1H,6H)-dione | |
| 1.4.3.4 | 0.00004 | - |
pH 7.4, 37°C | Homo sapiens | 3-bromo-1-methoxy-2-(4-methoxyphenyl)-2,3-dihydropyrrolo[3,4-f]indole-5,7(1H,6H)-dione | |
| 1.4.3.4 | 0.000048 | - |
pH 7.4, 37°C | Homo sapiens | safinamide | |
| 1.4.3.4 | 0.000049 | - |
pH 7.4, 37°C | Homo sapiens | 1-methoxy-2-(4-methoxyphenyl)-5,7-dioxo-1,2,3,5,6,7-hexahydropyrrolo[3,4-f]indole-3-carbaldehyde | |
| 1.4.3.4 | 0.000091 | - |
pH 7.4, 37°C | Homo sapiens | lazabemide | |
| 1.4.3.4 | 0.000092 | - |
pH 7.4, 37°C | Homo sapiens | 3-bromo-1-hydroxy-2-(4-methoxyphenyl)-2,3-dihydropyrrolo[3,4-f]indole-5,7(1H,6H)-dione | |
| 1.4.3.4 | 0.000175 | - |
pH 7.4, 37°C | Homo sapiens | 1-methoxy-5,7-dioxo-2-(thiophen-2-yl)-1,2,3,5,6,7-hexahydropyrrolo[3,4-f]indole-3-carbaldehyde | |
| 1.4.3.4 | 0.000178 | - |
pH 7.4, 37°C | Homo sapiens | 3-bromo-1-methoxy-6-methyl-2-(4-methylphenyl)-2,3-dihydropyrrolo[3,4-f]indole-5,7(1H,6H)-dione | |
| 1.4.3.4 | 0.000184 | - |
pH 7.4, 37°C | Homo sapiens | 1-methoxy-2-(4-methylphenyl)-5,7-dioxo-1,2,3,5,6,7-hexahydropyrrolo[3,4-f]indole-3-carbaldehyde | |
| 1.4.3.4 | 0.000193 | - |
pH 7.4, 37°C | Homo sapiens | (2E)-3-chloro-3-(4-methylphenyl)-2-(6-nitro-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)prop-2-enal | |
| 1.4.3.4 | 0.000447 | - |
pH 7.4, 37°C | Homo sapiens | 1-hydroxy-2-(4-methoxyphenyl)-2,3-dihydropyrrolo[3,4-f]indole-5,7(1H,6H)-dione | |
| 1.4.3.4 | 0.000458 | - |
pH 7.4, 37°C | Homo sapiens | 3-bromo-1-hydroxy-2-(4-methylphenyl)-2,3-dihydropyrrolo[3,4-f]indole-5,7(1H,6H)-dione | |
| 1.4.3.4 | 0.000529 | - |
pH 7.4, 37°C | Homo sapiens | 1-methoxy-5,7-dioxo-2-phenyl-1,2,3,5,6,7-hexahydropyrrolo[3,4-f]indole-3-carbaldehyde | |
| 1.4.3.4 | 0.000532 | - |
pH 7.4, 37°C | Homo sapiens | 3-(4-methoxybenzoyl)-1H-indole-5,6-dicarbonitrile | |
| 1.4.3.4 | 0.000605 | - |
pH 7.4, 37°C | Homo sapiens | 3-bromo-1-methoxy-2-(4-methoxyphenyl)-2,3-dihydropyrrolo[3,4-f]indole-5,7(1H,6H)-dione | |
| 1.4.3.4 | 0.000734 | - |
pH 7.4, 37°C | Homo sapiens | 3-bromo-1-hydroxy-2-(4-methylphenyl)-2,3-dihydropyrrolo[3,4-f]indole-5,7(1H,6H)-dione | |
| 1.4.3.4 | 0.000813 | - |
pH 7.4, 37°C | Homo sapiens | 3-(4-methoxybenzoyl)-1H-indole-5,6-dicarbonitrile | |
| 1.4.3.4 | 0.00087 | - |
pH 7.4, 37°C | Homo sapiens | 1-methoxy-2-(4-methoxyphenyl)-5,7-dioxo-1,2,3,5,6,7-hexahydropyrrolo[3,4-f]indole-3-carbaldehyde | |
| 1.4.3.4 | 0.00105 | - |
pH 7.4, 37°C | Homo sapiens | 3-bromo-1-hydroxy-2-phenyl-2,3-dihydropyrrolo[3,4-f]indole-5,7(1H,6H)-dione | |
| 1.4.3.4 | 0.00119 | - |
pH 7.4, 37°C | Homo sapiens | 3-acetyl-1-(acetyloxy)-2-(thiophen-2-yl)-1H-indole-5,6-dicarbonitrile | |
| 1.4.3.4 | 0.00119 | - |
pH 7.4, 37°C | Homo sapiens | 3-bromo-1-hydroxy-2-(4-methoxyphenyl)-2,3-dihydropyrrolo[3,4-f]indole-5,7(1H,6H)-dione | |
| 1.4.3.4 | 0.00129 | - |
pH 7.4, 37°C | Homo sapiens | 1-methoxy-2-(4-methylphenyl)-5,7-dioxo-1,2,3,5,6,7-hexahydropyrrolo[3,4-f]indole-3-carbaldehyde | |
| 1.4.3.4 | 0.00132 | - |
pH 7.4, 37°C | Homo sapiens | 3-bromo-1-hydroxy-2-phenyl-2,3-dihydropyrrolo[3,4-f]indole-5,7(1H,6H)-dione | |
| 1.4.3.4 | 0.00142 | - |
pH 7.4, 37°C | Homo sapiens | (2E)-3-chloro-2-(6-nitro-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)-3-phenylprop-2-enal | |
| 1.4.3.4 | 0.0022 | - |
pH 7.4, 37°C | Homo sapiens | 1-hydroxy-3-(4-methylbenzoyl)pyrrolo[3,4-f]indole-5,7(1H,6H)-dione | |
| 1.4.3.4 | 0.00222 | - |
pH 7.4, 37°C | Homo sapiens | (2E)-3-chloro-2-(6-nitro-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)-3-(thiophen-2-yl)prop-2-enal | |
| 1.4.3.4 | 0.00231 | - |
pH 7.4, 37°C | Homo sapiens | 1-methoxy-5,7-dioxo-2-phenyl-1,2,3,5,6,7-hexahydropyrrolo[3,4-f]indole-3-carbaldehyde | |
| 1.4.3.4 | 0.00279 | - |
pH 7.4, 37°C | Homo sapiens | 3-butanoyl-1-(butanoyloxy)-2-(thiophen-2-yl)-1H-indole-5,6-dicarbonitrile | |
| 1.4.3.4 | 0.00307 | - |
pH 7.4, 37°C | Homo sapiens | 1-hydroxy-2-(4-methoxyphenyl)-2,3-dihydropyrrolo[3,4-f]indole-5,7(1H,6H)-dione | |
| 1.4.3.4 | 0.00317 | - |
pH 7.4, 37°C | Homo sapiens | 3-acetyl-1-(acetyloxy)-2-(thiophen-2-yl)-1H-indole-5,6-dicarbonitrile | |
| 1.4.3.4 | 0.00357 | - |
pH 7.4, 37°C | Homo sapiens | 3-acetyl-1-(acetyloxy)-2-(4-methoxyphenyl)-1H-indole-5,6-dicarbonitrile | |
| 1.4.3.4 | 0.00392 | - |
pH 7.4, 37°C | Homo sapiens | toloxatone | |
| 1.4.3.4 | 0.00399 | - |
pH 7.4, 37°C | Homo sapiens | 3-benzoyl-1-hydroxypyrrolo[3,4-f]indole-5,7(1H,6H)-dione | |
| 1.4.3.4 | 0.00405 | - |
pH 7.4, 37°C | Homo sapiens | (2E)-3-chloro-3-(4-methylphenyl)-2-(6-nitro-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)prop-2-enal | |
| 1.4.3.4 | 0.00459 | - |
pH 7.4, 37°C | Homo sapiens | (2E)-3-chloro-2-(6-nitro-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)-3-phenylprop-2-enal | |
| 1.4.3.4 | 0.00547 | - |
pH 7.4, 37°C | Homo sapiens | (2E)-3-chloro-2-(6-nitro-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)-3-(thiophen-2-yl)prop-2-enal | |
| 1.4.3.4 | 0.00732 | - |
pH 7.4, 37°C | Homo sapiens | 1-hydroxy-3-(4-methylbenzoyl)pyrrolo[3,4-f]indole-5,7(1H,6H)-dione | |
| 1.4.3.4 | 0.00797 | - |
pH 7.4, 37°C | Homo sapiens | 2-(4-methylphenyl)-3-propanoyl-1-(propanoyloxy)-1H-indole-5,6-dicarbonitrile | |
| 1.4.3.4 | 0.00963 | - |
pH 7.4, 37°C | Homo sapiens | 3-butanoyl-1-(butanoyloxy)-2-(thiophen-2-yl)-1H-indole-5,6-dicarbonitrile | |
| 1.4.3.4 | 0.00982 | - |
pH 7.4, 37°C | Homo sapiens | 3-acetyl-1-(acetyloxy)-2-(4-methoxyphenyl)-1H-indole-5,6-dicarbonitrile | |
| 1.4.3.4 | 0.0125 | - |
pH 7.4, 37°C | Homo sapiens | 1-hydroxy-3-(4-methoxybenzoyl)-1H-indole-5,6-dicarboxylic acid | |
| 1.4.3.4 | 0.0135 | - |
pH 7.4, 37°C | Homo sapiens | 1-hydroxy-3-propanoyl-2-(thiophen-2-yl)-1H-indole-5,6-dicarbonitrile | |
| 1.4.3.4 | 0.0135 | - |
pH 7.4, 37°C | Homo sapiens | 3-benzoyl-1-hydroxy-1H-indole-5,6-dicarboxylic acid | |
| 1.4.3.4 | 0.0138 | - |
pH 7.4, 37°C | Homo sapiens | 3-benzoyl-1-hydroxypyrrolo[3,4-f]indole-5,7(1H,6H)-dione | |
| 1.4.3.4 | 0.0139 | - |
pH 7.4, 37°C | Homo sapiens | 1-hydroxy-2-(4-methylphenyl)-3-propanoyl-1H-indole-5,6-dicarbonitrile | |
| 1.4.3.4 | 0.0157 | - |
pH 7.4, 37°C | Homo sapiens | 1-methoxy-5,7-dioxo-2-(thiophen-2-yl)-1,2,3,5,6,7-hexahydropyrrolo[3,4-f]indole-3-carbaldehyde | |
| 1.4.3.4 | 0.0157 | - |
pH 7.4, 37°C | Homo sapiens | 3-acetyl-1-hydroxy-2-(4-methoxyphenyl)-1H-indole-5,6-dicarbonitrile | |
| 1.4.3.4 | 0.0166 | - |
pH 7.4, 37°C | Homo sapiens | 1-hydroxy-3-propanoyl-2-(thiophen-2-yl)-1H-indole-5,6-dicarbonitrile | |
| 1.4.3.4 | 0.0179 | - |
pH 7.4, 37°C | Homo sapiens | 1-hydroxy-2-(4-methylphenyl)-3-propanoyl-1H-indole-5,6-dicarbonitrile | |
| 1.4.3.4 | 0.018 | - |
pH 7.4, 37°C | Homo sapiens | 3-acetyl-1-hydroxy-2-(thiophen-2-yl)-1H-indole-5,6-dicarbonitrile | |
| 1.4.3.4 | 0.0191 | - |
pH 7.4, 37°C | Homo sapiens | 3-butanoyl-1-(butanoyloxy)-2-(4-methylphenyl)-1H-indole-5,6-dicarbonitrile | |
| 1.4.3.4 | 0.0214 | - |
pH 7.4, 37°C | Homo sapiens | 3-acetyl-1-hydroxy-2-(thiophen-2-yl)-1H-indole-5,6-dicarbonitrile | |
| 1.4.3.4 | 0.0216 | - |
pH 7.4, 37°C | Homo sapiens | 1-hydroxy-3-(4-methoxybenzoyl)-1H-indole-5,6-dicarboxylic acid | |
| 1.4.3.4 | 0.0222 | - |
pH 7.4, 37°C | Homo sapiens | 2-(4-methylphenyl)-3-propanoyl-1-(propanoyloxy)-1H-indole-5,6-dicarbonitrile | |
| 1.4.3.4 | 0.0222 | - |
pH 7.4, 37°C | Homo sapiens | 3-butanoyl-1-(butanoyloxy)-2-(4-methylphenyl)-1H-indole-5,6-dicarbonitrile | |
| 1.4.3.4 | 0.0251 | - |
pH 7.4, 37°C | Homo sapiens | 3-acetyl-1-hydroxy-2-(4-methoxyphenyl)-1H-indole-5,6-dicarbonitrile | |
| 1.4.3.4 | 0.027 | - |
pH 7.4, 37°C | Homo sapiens | 1-hydroxy-3-(4-methoxybenzoyl)pyrrolo[3,4-f]indole-5,7(1H,6H)-dione | |
| 1.4.3.4 | 0.0356 | - |
pH 7.4, 37°C | Homo sapiens | 3-acetyl-1-(acetyloxy)-2-phenyl-1H-indole-5,6-dicarbonitrile | |
| 1.4.3.4 | 0.0419 | - |
pH 7.4, 37°C | Homo sapiens | 3-acetyl-1-(acetyloxy)-2-phenyl-1H-indole-5,6-dicarbonitrile | |
| 1.4.3.4 | 0.0456 | - |
pH 7.4, 37°C | Homo sapiens | 3-benzoyl-1-hydroxy-1H-indole-5,6-dicarboxylic acid | |
| 1.4.3.4 | 0.0471 | - |
pH 7.4, 37°C | Homo sapiens | 3-acetyl-1-hydroxy-2-(4-methylphenyl)-1H-indole-5,6-dicarbonitrile | |
| 1.4.3.4 | 0.0676 | - |
pH 7.4, 37°C | Homo sapiens | 3-acetyl-1-hydroxy-2-phenyl-1H-indole-5,6-dicarbonitrile | |
| 1.4.3.4 | 0.115 | - |
pH 7.4, 37°C | Homo sapiens | 3-acetyl-1-hydroxy-2-phenyl-1H-indole-5,6-dicarbonitrile | |
| 1.4.3.4 | 0.117 | - |
pH 7.4, 37°C | Homo sapiens | 1-hydroxy-3-(4-methoxybenzoyl)pyrrolo[3,4-f]indole-5,7(1H,6H)-dione |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 1.4.3.4 | drug target | active monoamine oxidase inhibitors represent suitable leads for the development of drugs for neurodegenerative and neuropsychiatric disorders such as Parkinson's disease and depression. Monoamine oxidase inhibitors are also of interest for the treatment of prostate cancer, certain types of cardiomyopathies and Alzheimer's disease | Homo sapiens |
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