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Literature summary extracted from

  • Wen, Y.; Peng, L.; Zhou, Y.; Peng, T.; Chen, Y.; Cheng, X.; Chen, Y.; Yang, J.
    Discovery and application of methionine sulfoxide reductase B for preparation of (S)-sulfoxides through kinetic resolution (2020), Catal. Commun., 136, 105908 .
No PubMed abstract available

Application

EC Number Application Comment Organism
1.8.4.12 synthesis application of methionine sulfoxide reductase B for preparation of (S)-sulfoxides through kinetic resolution of racemic sulfoxides. The kinetic resolution of rac-sulfoxides is successfully accomplished at substrate concentrations up to 50 mM (7.8 g/l) when catalyzed by akMsrB whole-cell catalyst. The study supports that asymmetric reductive resolution of rac-sulfoxides catalysed by MsrB can become an effective strategy for green synthesis of optically pure sulfoxides Acidovorax sp. KKS102

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.8.4.12 expression in Escherichia coli Acidovorax sp. KKS102

Organism

EC Number Organism UniProt Comment Textmining
1.8.4.12 Acidovorax sp. KKS102 K0HZZ3
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.4.12 racemic (ethanesulfinyl)benzene + dithiothreitol specifically reduces the (R)-enantiomer of methionine sulfoxide to methionine, 93.1% ee Acidovorax sp. KKS102 (ethylsulfanyl)benzene + [(S)-ethanesulfinyl]benzene + dithiothreitol disulfide + H2O
-
 ?
1.8.4.12 racemic (methanesulfinyl)benzene + dithiothreitol specifically reduces the (R)-enantiomer of methionine sulfoxide to methionine, 96% ee Acidovorax sp. KKS102 (methylsulfanyl)benzene + [(S)-methanesulfinyl]benzene + dithiothreitol disulfide + H2O
-
 ?
1.8.4.12 racemic 1-(methanesulfinyl)-4-methylbenzene + dithiothreitol specifically reduces the (R)-enantiomer of methionine sulfoxide to methionine, 96.4% ee Acidovorax sp. KKS102 1-methyl-4-(methylsulfanyl)benzene + 1-[(S)-methanesulfinyl]-4-methylbenzene + dithiothreitol disulfide + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.8.4.12 methionine sulfoxide reductase B
-
 Acidovorax sp. KKS102
1.8.4.12 MsrB
-
 Acidovorax sp. KKS102