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Literature summary extracted from

  • Romani, M.; Daga, A.; Forlani, A.; Pistillo, M.P.; Banelli, B.
    Targeting of histone demethylases KDM5A and KDM6B inhibits the proliferation of temozolomide-resistant glioblastoma cells (2019), Cancers (Basel), 11, 878 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.11.67 JIB 04 inhibitor is active against native and temozolomide-resistant glioblastoma cells. GSK J4, inhibitor of lysine demethylase KDM6B, EC 1.14.11.68, and JIB 04 strongly synergize and are a potent combination against temozolomide-resistant glioblastoma cells Homo sapiens
1.14.11.68 GSKJ4 inhibitor is active against native and temozolomide-resistant glioblastoma cells, albeit at at a lower effcacy than JIB 04, inhibitor of lysine demethylase KDM5A, EC 1.14.11.67. GSK J4 and JIB 04 strongly synergize and are a potent combination against temozolomide-resistant glioblastoma cells. GSK J4 does not synergize with temozolomide Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.14.11.67 Homo sapiens P29375
-
-
1.14.11.68 Homo sapiens O15054 isoform KDM6B
-

Synonyms

EC Number Synonyms Comment Organism
1.14.11.67 KDM5A
-
 Homo sapiens
1.14.11.68 KDM6B
-
 Homo sapiens