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Literature summary extracted from

  • McGarry, D.J.; Armstrong, G.; Castino, G.; Mason, S.; Clark, W.; Shaw, R.; McGarry, L.; Blyth, K.; Olson, M.F.
    MICAL1 regulates actin cytoskeleton organization, directional cell migration and the growth of human breast cancer cells as orthotopic xenograft tumours (2021), Cancer Lett., 519, 226-236 .
    View publication on PubMed

Application

EC Number Application Comment Organism
1.14.13.225 medicine elevated MICAL1 gene expression is observed in invasive breast cancer samples from human patients relative to normal tissue, while MICAL1 amplification or point mutations are associated with reduced progression free survival Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Organism

EC Number Organism UniProt Comment Textmining
1.14.13.225 Homo sapiens Q8TDZ2 isoform MICAL1, cf. EC 1.6.3.1
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.13.225 MDA-MB-231 cell
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 Homo sapiens
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Synonyms

EC Number Synonyms Comment Organism
1.14.13.225 MICAL1 cf. EC 1.6.3.1 Homo sapiens

General Information

EC Number General Information Comment Organism
1.14.13.225 physiological function MICAL1 gene disruption in MDA-MB-231 cells knocks out protein expression, which affects F-actin organization, cell size and motility. MICAL1 deletion significantly affects the expression of over 700 genes, with the majority being reduced in their expression levels. Receptor regulator activity is the most significant negatively enriched molecular function gene set. MICAL1 deletion on is also associated with changes in the expression of several serum-response factor regulated genes. MICAL1 disruption attenuates breast cancer tumour growth in vivo Homo sapiens