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Literature summary extracted from

  • Liang, L.; Yu, S.; Li, Q.; Wang, X.; Wang, D.; Xi, Z.
    Design, synthesis, and molecular simulation studies of N-phenyltetrahydroquinazolinones as protoporphyrinogen IX oxidase inhibitors (2021), Bioorg. Med. Chem., 39, 116165 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.3.4 1-(allyloxy)-1-oxopropan-2-yl 2-chloro-4-fluoro-5-(4-oxo-5,6,7,8-tetrahydroquinazolin-3(4H)-yl)benzoate
-
 Nicotiana tabacum
1.3.3.4 1-(tert-butoxy)-1-oxopropan-2-yl 2-chloro-4-fluoro-5-(4-oxo-5,6,7,8-tetrahydroquinazolin-3(4H)-yl)benzoate
-
 Nicotiana tabacum
1.3.3.4 1-ethoxy-1-oxopropan-2-yl 2-chloro-4-fluoro-5-(4-oxo-5,6,7,8-tetrahydroquinazolin-3(4H)-yl)benzoate
-
 Nicotiana tabacum
1.3.3.4 1-oxo-1-(prop-2-yn-1-yloxy)propan-2-yl 2-chloro-4-fluoro-5-(4-oxo-5,6,7,8-tetrahydroquinazolin-3(4H)-yl)benzoate
-
 Nicotiana tabacum
1.3.3.4 2-(allyloxy)-2-oxoethyl 2-chloro-4-fluoro-5-(4-oxo-5,6,7,8-tetrahydroquinazolin-3(4H)-yl)benzoate
-
 Nicotiana tabacum
1.3.3.4 2-(tert-butoxy)-2-oxoethyl 2-chloro-4-fluoro-5-(4-oxo-5,6,7,8-tetrahydroquinazolin-3(4H)-yl)benzoate
-
 Nicotiana tabacum
1.3.3.4 2-chloro-N-(cyanomethyl)-4-fluoro-5-(4-oxo-5,6,7,8-tetrahydroquinazolin-3(4H)-yl)benzenesulfonamide
-
 Nicotiana tabacum
1.3.3.4 2-ethoxy-2-oxoethyl 2-chloro-4-fluoro-5-(4-oxo-5,6,7,8-tetrahydroquinazolin-3(4H)-yl)benzoate
-
 Nicotiana tabacum
1.3.3.4 2-oxo-2-(prop-2-yn-1-yloxy)ethyl 2-chloro-4-fluoro-5-(4-oxo-5,6,7,8-tetrahydroquinazolin-3(4H)-yl)benzoate
-
 Nicotiana tabacum
1.3.3.4 allyl 2-chloro-4-fluoro-5-(4-oxo-5,6,7,8-tetrahydroquinazolin-3(4H)-yl)benzoate
-
 Nicotiana tabacum
1.3.3.4 bencarbazone
-
 Nicotiana tabacum
1.3.3.4 benzyl 2-chloro-4-fluoro-5-(4-oxo-5,6,7,8-tetrahydroquinazolin-3(4H)-yl)benzoate
-
 Nicotiana tabacum
1.3.3.4 bifenox
-
 Nicotiana tabacum
1.3.3.4 butafenacil
-
 Nicotiana tabacum
1.3.3.4 butyl 2-chloro-4-fluoro-5-(4-oxo-5,6,7,8-tetrahydroquinazolin-3(4H)-yl)benzoate
-
 Nicotiana tabacum
1.3.3.4 ethoxyfen-ethyl
-
 Nicotiana tabacum
1.3.3.4 ethyl ((2-chloro-4-fluoro-5-(4-oxo-5,6,7,8-tetrahydroquinazolin-3(4H)-yl)phenyl)sulfonyl)alaninate
-
 Nicotiana tabacum
1.3.3.4 ethyl ((2-chloro-4-fluoro-5-(4-oxo-5,6,7,8-tetrahydroquinazolin-3(4H)-yl)phenyl)sulfonyl)glycinate
-
 Nicotiana tabacum
1.3.3.4 ethyl 2-chloro-4-fluoro-5-(4-oxo-5,6,7,8-tetrahydroquinazolin-3(4H)-yl)benzoate
-
 Nicotiana tabacum
1.3.3.4 fluazolate
-
 Nicotiana tabacum
1.3.3.4 flumioxazin
-
 Nicotiana tabacum
1.3.3.4 fluoroglycofen-ethyl
-
 Nicotiana tabacum
1.3.3.4 formesafen
-
 Nicotiana tabacum
1.3.3.4 halosafen
-
 Nicotiana tabacum
1.3.3.4 isopropyl 2-chloro-4-fluoro-5-(4-oxo-5,6,7,8-tetrahydroquinazolin-3(4H)-yl)benzoate
-
 Nicotiana tabacum
1.3.3.4 lactofen
-
 Nicotiana tabacum
1.3.3.4 methyl ((2-chloro-4-fluoro-5-(4-oxo-5,6,7,8-tetrahydroquinazolin-3(4H)-yl)phenyl)sulfonyl)glycinate
-
 Nicotiana tabacum
1.3.3.4 methyl 2-chloro-4-fluoro-5-(4-oxo-5,6,7,8-tetrahydroquinazolin-3(4H)-yl)benzoate
-
 Nicotiana tabacum
1.3.3.4 profluazol
-
 Nicotiana tabacum
1.3.3.4 prop-2-yn-1-yl 2-chloro-4-fluoro-5-(4-oxo-5,6,7,8-tetrahydroquinazolin-3(4H)-yl)benzoate
-
 Nicotiana tabacum
1.3.3.4 propyl 2-chloro-4-fluoro-5-(4-oxo-5,6,7,8-tetrahydroquinazolin-3(4H)-yl)benzoate
-
 Nicotiana tabacum
1.3.3.4 saflufenacil
-
 Nicotiana tabacum
1.3.3.4 sulfentrazone
-
 Nicotiana tabacum
1.3.3.4 tert-butyl((2-chloro-4-fluoro-5-(4-oxo-5,6,7,8-tetrahydroquinazolin-3(4H)-yl)phenyl)sulfonyl)glycinate
-
 Nicotiana tabacum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.3.4 protoporphyrinogen IX + 3 O2 Nicotiana tabacum
-
 protoporphyrin IX + 3 H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.3.4 Nicotiana tabacum
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.3.4 protoporphyrinogen IX + 3 O2
-
 Nicotiana tabacum protoporphyrin IX + 3 H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.3.4 PPO
-
 Nicotiana tabacum
1.3.3.4 protoporphyrinogen IX oxidase
-
 Nicotiana tabacum

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.3.3.4 0.000004
-
 1-(tert-butoxy)-1-oxopropan-2-yl 2-chloro-4-fluoro-5-(4-oxo-5,6,7,8-tetrahydroquinazolin-3(4H)-yl)benzoate pH and temperature not specified in the publication Nicotiana tabacum
1.3.3.4 0.000005
-
 2-(tert-butoxy)-2-oxoethyl 2-chloro-4-fluoro-5-(4-oxo-5,6,7,8-tetrahydroquinazolin-3(4H)-yl)benzoate pH and temperature not specified in the publication Nicotiana tabacum
1.3.3.4 0.000005
-
 ethyl ((2-chloro-4-fluoro-5-(4-oxo-5,6,7,8-tetrahydroquinazolin-3(4H)-yl)phenyl)sulfonyl)alaninate pH and temperature not specified in the publication Nicotiana tabacum
1.3.3.4 0.000006
-
 1-ethoxy-1-oxopropan-2-yl 2-chloro-4-fluoro-5-(4-oxo-5,6,7,8-tetrahydroquinazolin-3(4H)-yl)benzoate pH and temperature not specified in the publication Nicotiana tabacum
1.3.3.4 0.000006
-
 ethyl ((2-chloro-4-fluoro-5-(4-oxo-5,6,7,8-tetrahydroquinazolin-3(4H)-yl)phenyl)sulfonyl)glycinate pH and temperature not specified in the publication Nicotiana tabacum
1.3.3.4 0.000007
-
 butyl 2-chloro-4-fluoro-5-(4-oxo-5,6,7,8-tetrahydroquinazolin-3(4H)-yl)benzoate pH and temperature not specified in the publication Nicotiana tabacum
1.3.3.4 0.000008
-
 propyl 2-chloro-4-fluoro-5-(4-oxo-5,6,7,8-tetrahydroquinazolin-3(4H)-yl)benzoate pH and temperature not specified in the publication Nicotiana tabacum
1.3.3.4 0.000009
-
 ethyl 2-chloro-4-fluoro-5-(4-oxo-5,6,7,8-tetrahydroquinazolin-3(4H)-yl)benzoate pH and temperature not specified in the publication Nicotiana tabacum
1.3.3.4 0.00001
-
 2-(allyloxy)-2-oxoethyl 2-chloro-4-fluoro-5-(4-oxo-5,6,7,8-tetrahydroquinazolin-3(4H)-yl)benzoate pH and temperature not specified in the publication Nicotiana tabacum
1.3.3.4 0.00001
-
 methyl ((2-chloro-4-fluoro-5-(4-oxo-5,6,7,8-tetrahydroquinazolin-3(4H)-yl)phenyl)sulfonyl)glycinate pH and temperature not specified in the publication Nicotiana tabacum
1.3.3.4 0.000011
-
 1-(allyloxy)-1-oxopropan-2-yl 2-chloro-4-fluoro-5-(4-oxo-5,6,7,8-tetrahydroquinazolin-3(4H)-yl)benzoate pH and temperature not specified in the publication Nicotiana tabacum
1.3.3.4 0.000012
-
 1-oxo-1-(prop-2-yn-1-yloxy)propan-2-yl 2-chloro-4-fluoro-5-(4-oxo-5,6,7,8-tetrahydroquinazolin-3(4H)-yl)benzoate pH and temperature not specified in the publication Nicotiana tabacum
1.3.3.4 0.000012
-
 isopropyl 2-chloro-4-fluoro-5-(4-oxo-5,6,7,8-tetrahydroquinazolin-3(4H)-yl)benzoate pH and temperature not specified in the publication Nicotiana tabacum
1.3.3.4 0.000013
-
 2-chloro-N-(cyanomethyl)-4-fluoro-5-(4-oxo-5,6,7,8-tetrahydroquinazolin-3(4H)-yl)benzenesulfonamide pH and temperature not specified in the publication Nicotiana tabacum
1.3.3.4 0.000014
-
 2-oxo-2-(prop-2-yn-1-yloxy)ethyl 2-chloro-4-fluoro-5-(4-oxo-5,6,7,8-tetrahydroquinazolin-3(4H)-yl)benzoate pH and temperature not specified in the publication Nicotiana tabacum
1.3.3.4 0.000014
-
 prop-2-yn-1-yl 2-chloro-4-fluoro-5-(4-oxo-5,6,7,8-tetrahydroquinazolin-3(4H)-yl)benzoate pH and temperature not specified in the publication Nicotiana tabacum
1.3.3.4 0.000014
-
 tert-butyl((2-chloro-4-fluoro-5-(4-oxo-5,6,7,8-tetrahydroquinazolin-3(4H)-yl)phenyl)sulfonyl)glycinate pH and temperature not specified in the publication Nicotiana tabacum
1.3.3.4 0.000015
-
 benzyl 2-chloro-4-fluoro-5-(4-oxo-5,6,7,8-tetrahydroquinazolin-3(4H)-yl)benzoate pH and temperature not specified in the publication Nicotiana tabacum
1.3.3.4 0.000015
-
 methyl 2-chloro-4-fluoro-5-(4-oxo-5,6,7,8-tetrahydroquinazolin-3(4H)-yl)benzoate pH and temperature not specified in the publication Nicotiana tabacum
1.3.3.4 0.000019
-
 2-ethoxy-2-oxoethyl 2-chloro-4-fluoro-5-(4-oxo-5,6,7,8-tetrahydroquinazolin-3(4H)-yl)benzoate pH and temperature not specified in the publication Nicotiana tabacum
1.3.3.4 0.00002
-
 allyl 2-chloro-4-fluoro-5-(4-oxo-5,6,7,8-tetrahydroquinazolin-3(4H)-yl)benzoate pH and temperature not specified in the publication Nicotiana tabacum
1.3.3.4 0.000046
-
 flumioxazin pH and temperature not specified in the publication Nicotiana tabacum