EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
1.7.1.7 | D219A | the mutant shows reduced affinities for substrate and cofactor compared to the wild type enzyme | Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.7.1.7 | 0.0032 | - |
GMP | wild type enzyme, at pH 7.8 and 25°C | Homo sapiens | |
1.7.1.7 | 0.015 | - |
dGMP | wild type enzyme, at pH 7.8 and 25°C | Homo sapiens | |
1.7.1.7 | 0.016 | - |
NADPH | wild type enzyme, with GMP as cosubstrate, at pH 7.8 and 25°C | Homo sapiens | |
1.7.1.7 | 0.023 | - |
IMP | wild type enzyme, at pH 7.8 and 25°C | Homo sapiens | |
1.7.1.7 | 0.05 | - |
NADP+ | wild type enzyme, with IMP and NH3 as cosubstrates, at pH 7.8 and 25°C | Homo sapiens | |
1.7.1.7 | 0.101 | - |
NADPH | wild type enzyme, with GMP as cosubstrate, at pH 7.8 and 25°C | Homo sapiens | |
1.7.1.7 | 0.109 | - |
NADP+ | wild type enzyme, with IMP and NH3 as cosubstrates, at pH 7.8 and 25°C | Homo sapiens | |
1.7.1.7 | 0.12 | - |
NADPH | mutant enzyme D219A, with GMP as cosubstrate, at pH 7.8 and 25°C | Homo sapiens | |
1.7.1.7 | 0.14 | - |
dIMP | wild type enzyme, at pH 7.8 and 25°C | Homo sapiens | |
1.7.1.7 | 0.38 | - |
GMP | mutant enzyme D219A, at pH 7.8 and 25°C | Homo sapiens | |
1.7.1.7 | 0.42 | - |
NADP+ | mutant enzyme D219A, with IMP and NH3 as cosubstrates, at pH 7.8 and 25°C | Homo sapiens | |
1.7.1.7 | 1.1 | - |
IMP | mutant enzyme D219A, at pH 7.8 and 25°C | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.7.1.7 | GMP + NADPH + H+ | Homo sapiens | - |
IMP + NH3 + NADP+ | - |
r | |
1.7.1.7 | IMP + NH3 + NADP+ | Homo sapiens | - |
GMP + NADPH + H+ | - |
r |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.7.1.7 | Homo sapiens | Q9P2T1 | - |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.7.1.7 | Ni-NTA agarose resin column chromatography | Homo sapiens |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.7.1.7 | dGMP + NADPH + H+ | dGMP is a poor substrate | Homo sapiens | dIMP + NH3 + NADP+ | - |
r | |
1.7.1.7 | dIMP + NH3 + NADP+ | dIMP is a poor substrate | Homo sapiens | dGMP + NADPH + H+ | - |
r | |
1.7.1.7 | GMP + NADPH + H+ | - |
Homo sapiens | IMP + NH3 + NADP+ | - |
r | |
1.7.1.7 | IMP + NH3 + NADP+ | - |
Homo sapiens | GMP + NADPH + H+ | - |
r |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.7.1.7 | GMPR | - |
Homo sapiens |
1.7.1.7 | guanosine-5'-monophosphate reductase | - |
Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.7.1.7 | NADPH | - |
Homo sapiens |