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Literature summary extracted from

  • Vasta, J.D.; Choudhary, A.; Jensen, K.H.; McGrath, N.A.; Raines, R.T.
    Prolyl 4-hydroxylase substrate isosteres in which an (E)- or (Z)-alkene replaces the prolyl peptide bond (2017), Biochemistry, 56, 219-227 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.11.2 expression in Escherichia coli Homo sapiens
1.14.11.2 expression in Escherichia coli Chlamydomonas reinhardtii

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.14.11.2 29000
-
-
 Homo sapiens
1.14.11.2 29000
-
-
 Chlamydomonas reinhardtii

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.11.2 procollagen L-proline + 2-oxoglutarate + O2 Homo sapiens
-
 procollagen trans-4-hydroxy-L-proline + succinate + CO2
-
 ?
1.14.11.2 procollagen L-proline + 2-oxoglutarate + O2 Chlamydomonas reinhardtii
-
 procollagen trans-4-hydroxy-L-proline + succinate + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.11.2 Chlamydomonas reinhardtii A8IDI8
-
-
1.14.11.2 Homo sapiens P13674 P4H alpha 1 subunit
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.14.11.2
-
 Homo sapiens
1.14.11.2
-
 Chlamydomonas reinhardtii

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.11.2 procollagen L-proline + 2-oxoglutarate + O2
-
 Homo sapiens procollagen trans-4-hydroxy-L-proline + succinate + CO2
-
 ?
1.14.11.2 procollagen L-proline + 2-oxoglutarate + O2
-
 Chlamydomonas reinhardtii procollagen trans-4-hydroxy-L-proline + succinate + CO2
-
 ?
1.14.11.2 procollagen L-proline + 2-oxoglutarate + O2 the enzyme preferentially recognizes the cis conformation of the prolyl peptide bond Homo sapiens procollagen trans-4-hydroxy-L-proline + succinate + CO2
-
 ?
1.14.11.2 procollagen L-proline + 2-oxoglutarate + O2 the enzyme preferentially recognizes the cis conformation of the prolyl peptide bond Chlamydomonas reinhardtii procollagen trans-4-hydroxy-L-proline + succinate + CO2
-
 ?

Subunits

EC Number Subunits Comment Organism
1.14.11.2 monomer 1 * 29000 Homo sapiens
1.14.11.2 monomer 1 * 29000 Chlamydomonas reinhardtii

Synonyms

EC Number Synonyms Comment Organism
1.14.11.2 collagen prolyl 4-hydroxylase
-
 Homo sapiens
1.14.11.2 collagen prolyl 4-hydroxylase
-
 Chlamydomonas reinhardtii
1.14.11.2 CP4H1
-
 Homo sapiens
1.14.11.2 CrP4H-1
-
 Chlamydomonas reinhardtii

General Information

EC Number General Information Comment Organism
1.14.11.2 physiological function the enzyme catalyze a prevalent posttranslational modification, the hydroxylation of (2S)-proline residues in protocollagen strands. The ensuing (2S,4R)-4-hydroxyproline residues are necessary for the conformational stability of the collagen triple helix Homo sapiens
1.14.11.2 physiological function the enzyme catalyze a prevalent posttranslational modification, the hydroxylation of (2S)-proline residues in protocollagen strands. The ensuing (2S,4R)-4-hydroxyproline residues are necessary for the conformational stability of the collagen triple helix Chlamydomonas reinhardtii