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Literature summary extracted from

  • Yoshida, R.; Yoshimura, T.; Hemmi, H.
    Biosynthetic machinery for C25,C25-diether archaeal lipids from the hyperthermophilic archaeon Aeropyrum pernix (2018), Biochem. Biophys. Res. Commun., 497, 87-92 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.5.1.155
-
 Aeropyrum pernix

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.5.1.156 Mg2+ requires a divalent metal cation, such as Mg2+ Aeropyrum pernix

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.155 all-trans-pentaprenyl diphosphate + sn-glycerol 1-phosphate Aeropyrum pernix
-
 sn-3-O-(farnesylgeranyl)glycerol 1-phosphate + diphosphate
-
 ?
2.5.1.156 all-trans-pentaprenyl diphosphate + sn-3-O-(farnesylgeranyl)glycerol 1-phosphate Aeropyrum pernix
-
 2,3-bis-O-(geranylfarnesyl)-sn-glycerol 1-phosphate + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.155 Aeropyrum pernix
-
-
-
2.5.1.156 Aeropyrum pernix Q9YFU1
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.5.1.155
-
 Aeropyrum pernix

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.155 all-trans-pentaprenyl diphosphate + sn-glycerol 1-phosphate
-
 Aeropyrum pernix sn-3-O-(farnesylgeranyl)glycerol 1-phosphate + diphosphate
-
 ?
2.5.1.155 all-trans-pentaprenyl diphosphate + sn-glycerol 1-phosphate does not act on geranylgeranyl diphosphate Aeropyrum pernix sn-3-O-(farnesylgeranyl)glycerol 1-phosphate + diphosphate
-
 ?
2.5.1.156 all-trans-pentaprenyl diphosphate + sn-3-O-(farnesylgeranyl)glycerol 1-phosphate
-
 Aeropyrum pernix 2,3-bis-O-(geranylfarnesyl)-sn-glycerol 1-phosphate + diphosphate
-
 ?
2.5.1.156 all-trans-pentaprenyl diphosphate + sn-3-O-(farnesylgeranyl)glycerol 1-phosphate the enzyme cannot accept sn-3-(O-geranylgeranyl)glycerol 1-phosphate as the prenyl donor Aeropyrum pernix 2,3-bis-O-(geranylfarnesyl)-sn-glycerol 1-phosphate + diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.5.1.155 APE_0621
-
 Aeropyrum pernix
2.5.1.155 geranylfarnesylglyceryl phosphate synthase
-
 Aeropyrum pernix
2.5.1.155 GFGP synthase
-
 Aeropyrum pernix
2.5.1.156 2,3-bis-O-(farnesylgeranyl)-sn-glycerol 1-phosphate synthase
-
 Aeropyrum pernix
2.5.1.156 2,3-di-O-farnesylgeranylglyceryl synthase
-
 Aeropyrum pernix
2.5.1.156 DGFGP synthase
-
 Aeropyrum pernix
2.5.1.156 digeranylfarnesylglyceryl phosphate synthase
-
 Aeropyrum pernix

General Information

EC Number General Information Comment Organism
2.5.1.155 physiological function the enzyme catalyses the first pathway-specific step in the biosynthesis of the core membrane C25,C25-diether lipids in some archaea Aeropyrum pernix
2.5.1.156 physiological function the enzyme carries out the second prenyltransfer reaction involved in the formation of C25,C25 membrane diether-lipids in some archaea Aeropyrum pernix