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Literature summary extracted from

  • Tabrez, S.; Rahman, F.; Ali, R.; Akand, S.K.; Alaidarous, M.A.; Banawas, S.; Dukhyil, A.A.B.; Rub, A.
    Hesperidin targets Leishmania donovani sterol C-24 reductase to fight against leishmaniasis (2021), ACS Omega, 6, 8112-8118 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.72 hesperidin
-
 Leishmania donovani

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.1.72 ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADPH + H+ Leishmania donovani
-
 ergosterol + NADP+
-
 ?
1.3.1.72 ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADPH + H+ Leishmania donovani BPK282A1
-
 ergosterol + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.72 Leishmania donovani E9BQ02
-
-
1.3.1.72 Leishmania donovani BPK282A1 E9BQ02
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.72 amastigote
-
 Leishmania donovani
-
1.3.1.72 promastigote
-
 Leishmania donovani
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.72 ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADPH + H+
-
 Leishmania donovani ergosterol + NADP+
-
 ?
1.3.1.72 ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADPH + H+
-
 Leishmania donovani BPK282A1 ergosterol + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.1.72 sterol C-24 reductase
-
 Leishmania donovani

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.3.1.72 1.019
-
 pH and temperature not specified in the publication Leishmania donovani hesperidin