Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Hilbert, B.J.; Morris, B.L.; Ellis, K.C.; Paulsen, J.L.; Schiffer, C.A.; Grossman, S.R.; Royer, W.E.
    Structure-guided design of a high affinity inhibitor to human CtBP (2015), ACS Chem. Biol., 10, 1118-1127 .
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.1.1.428 enzyme in complex with phenylpyruvate is crystallized by hanging drop vapor diffusion against a reservoir solution containing 200 mM CaCl2, 100 mM HEPES pH 7.5, and 2.5 mM NAD+. Enzyme in complex with 2-hydroxyimino-3-phenylpropanoic acid is crystallized by vapor diffusion against a reservoir solution containing 75 mM CaCl2, 100 mM HEPES pH 7.5, and 1 mM NADH Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.428 2-(hydroxyimino)-3-phenylpropanoic acid
-
 Homo sapiens
1.1.1.428 phenylpyruvate
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.428 4-(methylsulfanyl)-2-oxobutanoate + NADH + H+ Homo sapiens
-
 (2R)-2-hydroxy-4-(methylsulfanyl)butanoate + NAD+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.428 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.428 4-(methylsulfanyl)-2-oxobutanoate + NADH + H+
-
 Homo sapiens (2R)-2-hydroxy-4-(methylsulfanyl)butanoate + NAD+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.428 C-terminal-binding protein 1
-
 Homo sapiens
1.1.1.428 CTBP1
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.428 NAD+
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.1.1.428 0.000745
-
 pH and temperature not specified in the publication Homo sapiens 2-(hydroxyimino)-3-phenylpropanoic acid
1.1.1.428 0.135
-
 pH and temperature not specified in the publication Homo sapiens phenylpyruvate