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Literature summary extracted from

  • Zhu, Q.; Pan, P.; Chen, X.; Wang, Y.; Zhang, S.; Mo, J.; Li, X.; Ge, R.S.
    Human placental 3beta-hydroxysteroid dehydrogenase/steroid ?5,4-isomerase 1 Identity, regulation and environmental inhibitors (2019), Toxicology, 425, 152253 .
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
1.1.1.145 C83A mutation produces fully active enzyme with elevated Km values for ligands Homo sapiens
1.1.1.145 C83S mutation in the active site abolishes the dehydrogenase and isomerase activities of the enzyme Homo sapiens
1.1.1.145 D257I complete loss of dehydrogenase and isomerase activities Homo sapiens
1.1.1.145 D258I complete loss of dehydrogenase and isomerase activities Homo sapiens
1.1.1.145 D35A/K36R double mutations cause conversion of the cofactor dependence from NAD+ to NADP+ Homo sapiens
1.1.1.145 K158Q complete loss of dehydrogenase activity Homo sapiens
1.1.1.145 S124A complete loss of dehydrogenase activity Homo sapiens
1.1.1.145 Y154F complete loss of dehydrogenase activity Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.145 (+)-gossypol potent inhibitor, competitive Homo sapiens
1.1.1.145 (-)-gossypol weak inhibitor, competitive Homo sapiens
1.1.1.145 bis (2-butoxyethyl) phthalate moderate inhibitor, competitive Homo sapiens
1.1.1.145 di-heptyl phthalate potent inhibitor, competitive Homo sapiens
1.1.1.145 di-n-butyl phthalate potent inhibitor, competitive Homo sapiens
1.1.1.145 di-n-octyl phthalate weak inhibitor Homo sapiens
1.1.1.145 dicyclohexyl phthalate moderate inhibitor, competitive Homo sapiens
1.1.1.145 HPTE potent inhibitor, competitive Homo sapiens
1.1.1.145 methoxychlor insecticide, potent inhibitor, competitive Homo sapiens
1.1.1.145 organotin can inhibit placental HSD3B1 activity, thus blocking the formation of progesterone and disrupting pregnancy Homo sapiens
1.1.1.145 tributyltin moderate inhibitor, competitive Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.145 mitochondrion
-
 Homo sapiens 5739
-
1.1.1.145 smooth endoplasmic reticulum membrane-bound enzyme Homo sapiens 5790
-

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.145 Homo sapiens P14060
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.145 mammary gland
-
 Homo sapiens
-
1.1.1.145 placenta intermediate trophoblast and syncytiotrophoblasts Homo sapiens
-
1.1.1.145 prostate gland
-
 Homo sapiens
-
1.1.1.145 skin
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.145 dehydroepiandrosterone + NAD+
-
 Homo sapiens androstenedione + NADH + H+
-
 ?
1.1.1.145 pregnenolone + NAD+
-
 Homo sapiens progesterone + NADH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.145 3beta-hydroxysteroid dehydrogenase/steroid DELTA5,4-isomerase
-
 Homo sapiens
1.1.1.145 HSD3B1
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
1.1.1.145 Homo sapiens GATA3 negatively regulates the expression of HSD3B1 down
1.1.1.145 Homo sapiens expression is regulated by GATA2 and TEF-5 transcription factors. GATA2 is the positively regulatory transcription factor up

General Information

EC Number General Information Comment Organism
1.1.1.145 metabolism HSD3B1 is a unique enzyme for progesterone synthesis and is also involved in the estrogen production in human placenta Homo sapiens