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Literature summary extracted from

  • Devambez, I.; van Dijk, J.; Benlefki, S.; Layalle, S.; Grau, Y.; Rogowski, K.; Parmentier, M.L.; Soustelle, L.
    Identification of DmTTLL5 as a major tubulin glutamylase in the Drosophila nervous system (2017), Sci. Rep., 7, 16254 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.3.2.61 n ATP + [tubulin]-L-glutamate + n L-glutamate Drosophila melanogaster overall reaction, the enzyme initiates microtubule glutamylation specifically on alpha-tubulin [tubulin]-(gamma-(poly-alpha-L-glutamyl)-L-glutamyl)-L-glutamate + n ADP + n phosphate
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 ?

Organism

EC Number Organism UniProt Comment Textmining
6.3.2.61 Drosophila melanogaster
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.3.2.61 brain
-
 Drosophila melanogaster
-
6.3.2.61 nervous system
-
 Drosophila melanogaster
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.2.61 n ATP + [tubulin]-L-glutamate + n L-glutamate overall reaction, the enzyme initiates microtubule glutamylation specifically on alpha-tubulin Drosophila melanogaster [tubulin]-(gamma-(poly-alpha-L-glutamyl)-L-glutamyl)-L-glutamate + n ADP + n phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.3.2.61 alpha-tubulin glutamylase
-
 Drosophila melanogaster
6.3.2.61 CG31108
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 Drosophila melanogaster
6.3.2.61 TTLL5
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 Drosophila melanogaster

General Information

EC Number General Information Comment Organism
6.3.2.61 malfunction isoform TTLL5 mutant flies are viable without any defect in vesicular axonal transport, synapse morphology and larval locomotion. Moreover, isoform TTLL5 mutant flies display normal negative geotaxis behavior and their lifespan is not altered Drosophila melanogaster
6.3.2.61 physiological function isoform TTLL5 is the major enzyme responsible for initiating neuronal mictotubule glutamylation specifically on alpha-tubulin Drosophila melanogaster