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Literature summary extracted from

  • Subramanian, K.; Gora, A.; Spruijt, R.; Mitusinska, K.; Suarez-Diez, M.; Martins Dos Santos, V.; Schaap, P.J.
    Modulating D-amino acid oxidase (DAAO) substrate specificity through facilitated solvent access (2018), PLoS ONE, 13, e0198990 .
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
1.4.3.3 L56T increase in activity towards D-alanine, decrease in activity towards D-serine, D-tryptophan Homo sapiens
1.4.3.3 additional information mutations in residues located on the loops on the border between the active site and the secondary binding pocket. Mutations modulate substrate specificity, product egress and enzyme activity Sus scrofa
1.4.3.3 additional information mutations in residues located on the loops on the border between the active site and the secondary binding pocket. Mutations modulate substrate specificity, product egress and enzyme activity Homo sapiens
1.4.3.3 T56L decrease in activity towards D-alanine, increase in activity towards D-serine, D-tryptophan Sus scrofa
1.4.3.3 Y55A slight reduction in activity towards D-alanine, D-serine, increase in activity towards D-tryptophan, D-histidine, D-methionine, D-phenylalanine, D-tyrosine Homo sapiens
1.4.3.3 Y55A strong reduction in activity towards D-alanine, D-serine, increase in activity towards D-tryptophan, D-phenylalanine, D-tyrosine, D-arginine Sus scrofa
1.4.3.3 Y55A/L56T about 40-60% reduction in activity towards D-alanine, D-serine, slight reduction in activity towards D-tryptophan Homo sapiens
1.4.3.3 Y55A/T56L decrease in activity towards D-alanine, D-serine, increase in activity towards D-tryptophan Sus scrofa
1.4.3.3 Y55W 20-40% reduction in activity towards D-alanine, D-serine, no change in activity towards D-tryptophan Homo sapiens
1.4.3.3 Y55W strong reduction in activity towards D-alanine, D-serine, increase in activity towards D-tryptophan Sus scrofa
1.4.3.3 Y55W/L56T 50-70% reduction in activity towards D-alanine, D-serine, no change in activity towards D-tryptophan Homo sapiens
1.4.3.3 Y55W/T56L increase in activity towards D-alanine, D-tryptophan, D-arginine, D-cysteine, D-phenylalanine, D-tyrosine, decrease in activity towards D-serine Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.3 Homo sapiens P14920
-
-
1.4.3.3 Sus scrofa P00371
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.3 D-alanine + H2O + O2
-
 Sus scrofa pyruvate + NH3 + H2O2
-
 ?
1.4.3.3 D-alanine + H2O + O2
-
 Homo sapiens pyruvate + NH3 + H2O2
-
 ?
1.4.3.3 D-serine + H2O + O2
-
 Sus scrofa 2-oxo-3-hydroxypropionate + NH3 + H2O2
-
 ?
1.4.3.3 D-serine + H2O + O2
-
 Homo sapiens 2-oxo-3-hydroxypropionate + NH3 + H2O2
-
 ?
1.4.3.3 D-tryptophan + H2O + O2
-
 Sus scrofa indol-3-pyruvate + NH3 + H2O2
-
 ?
1.4.3.3 D-tryptophan + H2O + O2
-
 Homo sapiens indol-3-pyruvate + NH3 + H2O2
-
 ?