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Literature summary extracted from

  • Yao, L.; Chen, W.; Song, K.; Han, C.; Gandhi, C.R.; Lim, K.; Wu, T.
    15-hydroxyprostaglandin dehydrogenase (15-PGDH) prevents lipopolysaccharide (LPS)-induced acute liver injury (2017), PLoS ONE, 12, e0176106 .
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
1.1.1.141 drug development induction of 15-hydroxyprostaglandin dehydrogenase expression or utilization of 15-keto-PGE2 analogue may have therapeutic benefits for the treatment of endotoxin-associated liver inflammation/injury Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.141 (5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ Mus musculus the enzyme catalyzes the oxidation of the 15(S)-hydroxyl group of prostaglandin E2 (PGE2), converting the proinflammatory PGE2 to the anti-inflammatory 15-keto-PGE2 (an endogenous ligand for peroxisome proliferator-activated receptor-gamma [PPAR-gamma]) (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
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 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.141 Mus musculus Q8VCC1
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-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.141 liver generation of transgenic mice with targeted expression of 15-hydroxyprostaglandin dehydrogenase in the liver Mus musculus
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.141 (5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+
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 Mus musculus (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
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 ?
1.1.1.141 (5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ the enzyme catalyzes the oxidation of the 15(S)-hydroxyl group of prostaglandin E2 (PGE2), converting the proinflammatory PGE2 to the anti-inflammatory 15-keto-PGE2 (an endogenous ligand for peroxisome proliferator-activated receptor-gamma [PPAR-gamma]) Mus musculus (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
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 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.141 15-PGDH
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 Mus musculus
1.1.1.141 NAD+-dependent 15-hydroxyprostaglandin dehydrogenase
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 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.141 NAD+
-
 Mus musculus

General Information

EC Number General Information Comment Organism
1.1.1.141 metabolism NAD+-dependent 15-hydroxyprostaglandin dehydrogenase protects against LPS/GalN-induced liver injury and the effect is mediated via 15-keto-PGE2, which activates PPAR-gamma in Kupffer cells and thus inhibits their ability to produce inflammatory cytokines Mus musculus