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Literature summary extracted from

  • Yin, J.; Wei, Y.; Liu, D.; Hu, Y.; Lu, Q.; Ang, E.L.; Zhao, H.; Zhang, Y.
    An extended bacterial reductive pyrimidine degradation pathway that enables nitrogen release from beta-alanine (2019), J. Biol. Chem., 294, 15662-15671 .
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.6.1.120 2.3
-
 beta-Alanine pH 8, temperature not specified in the publication Ureibacillus massiliensis
2.6.1.120 3.3
-
 2-oxoglutarate pH 8, temperature not specified in the publication Ureibacillus massiliensis
2.6.1.120 12
-
 taurine cosubstrate 2-oxoglutarate, pH 8, temperature not specified in the publication Ureibacillus massiliensis
2.6.1.120 46
-
 pyruvate cosubstrate beta-alanine, pH 8, temperature not specified in the publication Ureibacillus massiliensis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.6.1.120 beta-alanine + 2-oxoglutarate Ureibacillus massiliensis
-
 3-oxopropanoate + L-glutamate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.120 Ureibacillus massiliensis
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.120 beta-alanine + 2-oxoglutarate
-
 Ureibacillus massiliensis 3-oxopropanoate + L-glutamate
-
 ?
2.6.1.120 beta-alanine + 2-oxoglutarate
-
 Ureibacillus massiliensis 3-oxopropanoate + L-glutamate
-
 r
2.6.1.120 beta-alanine + oxaloacetate
-
 Ureibacillus massiliensis 3-oxopropanoate + ?
-
 r
2.6.1.120 beta-alanine + pyruvate
-
 Ureibacillus massiliensis 3-oxopropanoate + L-alanine
-
 r
2.6.1.120 taurine + 2-oxoglutarate
-
 Ureibacillus massiliensis ? + L-glutamate
-
 r

Synonyms

EC Number Synonyms Comment Organism
2.6.1.120 pydD
-
 Ureibacillus massiliensis

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.6.1.120 0.51
-
 taurine cosubstrate 2-oxoglutarate, pH 8, temperature not specified in the publication Ureibacillus massiliensis
2.6.1.120 1.25
-
 pyruvate cosubstrate beta-alanine, pH 8, temperature not specified in the publication Ureibacillus massiliensis
2.6.1.120 5.6
-
 2-oxoglutarate pH 8, temperature not specified in the publication Ureibacillus massiliensis
2.6.1.120 5.6
-
 beta-Alanine pH 8, temperature not specified in the publication Ureibacillus massiliensis

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.6.1.120 8
-
-
 Ureibacillus massiliensis

General Information

EC Number General Information Comment Organism
2.6.1.120 physiological function beta-alanine:2-oxoglutarate aminotransferase PydD and NAD(P)H-dependent malonic semialdehyde reductase PydE together convert beta-alanine into 3-hydroxypropionate and generated glutamate, thereby making the second nitrogen from the pyrimidine ring available for assimilation Ureibacillus massiliensis

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
2.6.1.120 0.027
-
 pyruvate cosubstrate beta-alanine, pH 8, temperature not specified in the publication Ureibacillus massiliensis
2.6.1.120 0.041
-
 taurine cosubstrate 2-oxoglutarate, pH 8, temperature not specified in the publication Ureibacillus massiliensis
2.6.1.120 1.7
-
 2-oxoglutarate pH 8, temperature not specified in the publication Ureibacillus massiliensis
2.6.1.120 2.4
-
 beta-Alanine pH 8, temperature not specified in the publication Ureibacillus massiliensis