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Literature summary extracted from

  • Lee, J.; Zhong, X.; Lee, J.; Surh, Y.; Na, H.
    15-Keto prostaglandin E2 induces heme oxygenase-1 expression through activation of Nrf2 in human colon epithelial CCD 841 CoN cells (2020), Arch. Biochem. Biophys., 679, 108162 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.141 (5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ Homo sapiens
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 (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.141 Homo sapiens P15428
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.141 CCD-841 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.141 (5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+
-
 Homo sapiens (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.141 15-PGDH
-
 Homo sapiens
1.1.1.141 NAD+-dependent 15-hydroxyprostaglandin dehydrogenase
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
1.1.1.141 metabolism the enzyme is a tumor suppressor in various malignancies including colon cancer. The product (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate (15-keto PGE2) stimulates the Nrf2-HO-1 axis through the generation of ROS in normal colon epithelial cells, which contributes to the potential role of this lipid mediator in preventing cancer development associated with oxidative stress and inflammatory tissue damage Homo sapiens