Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Fabian, S.J.; Maust, M.D.; Panaccione, D.G.
    Ergot alkaloid synthesis capacity of Penicillium camemberti (2018), Appl. Environ. Microbiol., 84, e01583-18 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.332 gene easD or fgaDH, ergot alkaloid synthesis (eas) genes are found clustered in the genomes of ergot alkaloid-producing fungi, genetic structure Aspergillus fumigatus
1.1.1.332 gene easD, ergot alkaloid synthesis (eas) genes are found clustered in the genomes of ergot alkaloid-producing fungi, genetic structure, DNA and amino acid sequence determination and comparison with the enzyme sequence from Penicilium biforme. The Penicillium camemberti genome contains a cluster of genes containing homologues to several eas genes and has or had (at one time in its evolutionary past) the ability to produce ergot alkaloids, expression analysis, the mRNAs are processed properly, as the cDNAs contain open reading frames, expression analysis Penicillium camemberti

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.332 chanoclavine-I + NAD+ Aspergillus fumigatus
-
 chanoclavine-I aldehyde + NADH + H+
-
 r
1.1.1.332 chanoclavine-I + NAD+ Aspergillus fumigatus CBS 101355
-
 chanoclavine-I aldehyde + NADH + H+
-
 r
1.1.1.332 chanoclavine-I + NAD+ Aspergillus fumigatus ATCC MYA-4609
-
 chanoclavine-I aldehyde + NADH + H+
-
 r
1.1.1.332 chanoclavine-I + NAD+ Aspergillus fumigatus FGSC A1100
-
 chanoclavine-I aldehyde + NADH + H+
-
 r
1.1.1.332 chanoclavine-I + NAD+ Aspergillus fumigatus Af293
-
 chanoclavine-I aldehyde + NADH + H+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.332 Aspergillus fumigatus Q4WZ66 Aspergillus fumigatus
-
1.1.1.332 Aspergillus fumigatus Af293 Q4WZ66 Aspergillus fumigatus
-
1.1.1.332 Aspergillus fumigatus ATCC MYA-4609 Q4WZ66 Aspergillus fumigatus
-
1.1.1.332 Aspergillus fumigatus CBS 101355 Q4WZ66 Aspergillus fumigatus
-
1.1.1.332 Aspergillus fumigatus FGSC A1100 Q4WZ66 Aspergillus fumigatus
-
1.1.1.332 Penicillium camemberti
-
-
-
1.1.1.332 Penicillium camemberti NRRL 874
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.332 chanoclavine-I + NAD+
-
 Penicillium camemberti chanoclavine-I aldehyde + NADH + H+
-
 r
1.1.1.332 chanoclavine-I + NAD+
-
 Aspergillus fumigatus chanoclavine-I aldehyde + NADH + H+
-
 r
1.1.1.332 chanoclavine-I + NAD+
-
 Aspergillus fumigatus CBS 101355 chanoclavine-I aldehyde + NADH + H+
-
 r
1.1.1.332 chanoclavine-I + NAD+
-
 Aspergillus fumigatus ATCC MYA-4609 chanoclavine-I aldehyde + NADH + H+
-
 r
1.1.1.332 chanoclavine-I + NAD+
-
 Aspergillus fumigatus FGSC A1100 chanoclavine-I aldehyde + NADH + H+
-
 r
1.1.1.332 chanoclavine-I + NAD+
-
 Aspergillus fumigatus Af293 chanoclavine-I aldehyde + NADH + H+
-
 r
1.1.1.332 chanoclavine-I + NAD+
-
 Penicillium camemberti NRRL 874 chanoclavine-I aldehyde + NADH + H+
-
 r

Synonyms

EC Number Synonyms Comment Organism
1.1.1.332 ChaDH
-
 Penicillium camemberti
1.1.1.332 ChaDH
-
 Aspergillus fumigatus
1.1.1.332 easD
-
 Penicillium camemberti
1.1.1.332 easD
-
 Aspergillus fumigatus
1.1.1.332 fgaDH
-
 Aspergillus fumigatus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.332 NAD+
-
 Penicillium camemberti
1.1.1.332 NAD+
-
 Aspergillus fumigatus
1.1.1.332 NADH
-
 Penicillium camemberti
1.1.1.332 NADH
-
 Aspergillus fumigatus

General Information

EC Number General Information Comment Organism
1.1.1.332 metabolism the enzyme is involved in the biosynthesis of festuclavine from dimethylallylpyrosphosphate and tryptophane, the ergot alkaloid pathway, overview. The product of the easD reaction, chanoclavine-I aldehyde, serves as a branch point intermediate that may be acted on by the products of different alleles of ergot alkaloid synthesis genes in different lineages to yield lysergic acid and its derivatives in the Clavicipitaceae or various clavine-type ergot alkaloids in the Eurotiales (including Neosartorya and Penicillium species) Penicillium camemberti
1.1.1.332 metabolism the enzyme is involved in the biosynthesis of festuclavine from dimethylallylpyrosphosphate and tryptophane, the ergot alkaloid pathway, overview. The product of the easD reaction, chanoclavine-I aldehyde, serves as a branch point intermediate that may be acted on by the products of different alleles of ergot alkaloid synthesis genes in different lineages to yield lysergic acid and its derivatives in the Clavicipitaceae or various clavine-type ergot alkaloids in the Eurotiales (including Neosartorya and Penicillium species) Aspergillus fumigatus
1.1.1.332 physiological function the clavine alkaloids of the animal pathogen Neosartorya fumigata (Aspergillus fumigatus) contribute to virulence Aspergillus fumigatus