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Literature summary extracted from

  • Sleiman, D.; Garcia, P.; Lagune, M.; Loch, J.; Haouz, A.; Taib, N.; Roethlisberger, P.; Gribaldo, S.; Marliere, P.; Kaminski, P.
    A third purine biosynthetic pathway encoded by aminoadenine-based viral DNA genomes (2021), Science, 372, 516-520 .
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
6.3.4.25 structure of apo-PurZ at 1.3 A resolution and structures in complex with ATP, with dGMP, ATP, and Mg2+, and with beta,gamma-methyleneadenosine 5'-triphosphate, dGMP, and aspartate Vibrio phage phiVC8

Organism

EC Number Organism UniProt Comment Textmining
6.3.4.25 cyanophage S-2L
-
-
-
6.3.4.25 Vibrio phage phiVC8 G3FFN6
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.4.25 ATP + dGMP + L-aspartate
-
 Vibrio phage phiVC8 ADP + phosphate + 2-amino-2'-deoxy-N6-[(2S)-succino]adenylate
-
 ?
6.3.4.25 ATP + dGMP + L-aspartate
-
 cyanophage S-2L ADP + phosphate + 2-amino-2'-deoxy-N6-[(2S)-succino]adenylate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.3.4.25 Adenylosuccinate synthetase
-
 Vibrio phage phiVC8
6.3.4.25 phiVC8_p27
-
 Vibrio phage phiVC8
6.3.4.25 purZ
-
 Vibrio phage phiVC8

General Information

EC Number General Information Comment Organism
6.3.4.25 physiological function cyanophage S-2L and Vibrio phage PhiVC8 encode a third purine pathway catalyzed by PurZ. PurZ condenses aspartate with deoxyguanylate into dSMP (N6-succino-2-amino-2'-deoxyadenylate), which undergoes defumarylation and phosphorylation to give dZTP (2-amino-2'-deoxyadenosine-5'-triphosphate), a substrate for the phage DNA polymerase Vibrio phage phiVC8
6.3.4.25 physiological function cyanophage S-2L and Vibrio phage PhiVC8 encode a third purine pathway catalyzed by PurZ. PurZ condenses aspartate with deoxyguanylate into dSMP (N6-succino-2-amino-2'-deoxyadenylate), which undergoes defumarylation and phosphorylation to give dZTP (2-amino-2'-deoxyadenosine-5'-triphosphate), a substrate for the phage DNA polymerase cyanophage S-2L