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Literature summary extracted from

  • Imle, R.; Wang, B.T.; Stuetzenberger, N.; Birkenhagen, J.; Tandon, A.; Carl, M.; Himmelreich, N.; Thiel, C.; Groene, H.J.; Poschet, G.; Voelkers, M.; Guelow, K.; Schroeder, A.; Carillo, S.; Mittermayr, S.; Bones, J.; Kaminski, M.M.; Koelker, S.; Sauer, S.W.
    ADP-dependent glucokinase regulates energy metabolism via ER-localized glucose sensing (2019), Sci. Rep., 9, 14248 .
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.147 endoplasmic reticulum
-
 Danio rerio 5783
-
2.7.1.147 endoplasmic reticulum
-
 Homo sapiens 5783
-

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.147 Danio rerio
-
-
-
2.7.1.147 Homo sapiens Q9BRR6
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.147 embryo
-
 Danio rerio
-
2.7.1.147 JURKAT cell
-
 Homo sapiens
-

Synonyms

EC Number Synonyms Comment Organism
2.7.1.147 ADP-dependent glucokinase
-
 Danio rerio
2.7.1.147 ADP-dependent glucokinase
-
 Homo sapiens
2.7.1.147 ADPGK
-
 Danio rerio
2.7.1.147 ADPGK
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.7.1.147 malfunction ADPGK knockdown in zebrafish embryos leads to short, dorsalized body axis induced by elevated apoptosis. ADPGK hypomorphic zebrafish display dysfunctional glucose metabolism Danio rerio
2.7.1.147 malfunction upon activation, ADPGK knockout Jurkat T cells display increased cell death and ER stress. The increase in cell death results from a metabolic catastrophe and knockout cells displayed severely disturbed energy metabolism hindering induction of Warburg phenotype Homo sapiens
2.7.1.147 physiological function the enzyme plays a critical role in T cell receptor activation-induced remodeling of energy metabolism. The enzyme is part of a glucose sensing system in the ER modulating metabolism via regulation of N- and O-glycosylation Danio rerio
2.7.1.147 physiological function the enzyme plays a critical role in T cell receptor activation-induced remodeling of energy metabolism. The enzyme is part of a glucose sensing system in the ER modulating metabolism via regulation of N- and O-glycosylation Homo sapiens