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Literature summary extracted from

  • Chen, P.; Zhou, Z.; Yao, X.; Pang, S.; Liu, M.; Jiang, W.; Jiang, J.; Zhang, Q.
    Capping enzyme mRNA-cap/RNGTT regulates hedgehog pathway activity by antagonizing protein kinase A (2017), Sci. Rep., 7, 2891 .
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.7.50 cytoplasm
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 Drosophila melanogaster 5737
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Organism

EC Number Organism UniProt Comment Textmining
2.7.7.50 Drosophila melanogaster
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-
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Synonyms

EC Number Synonyms Comment Organism
2.7.7.50 mRNA-cap the enzyme harbors RNA 5'-triphosphatase and mRNA 3'-guanylyltransferase domains Drosophila melanogaster

General Information

EC Number General Information Comment Organism
2.7.7.50 malfunction enzyme knockdown impairs wing development and represses Hedgehog pathway signalling activity. Enzyme knockdown downregulates transcription factor Cubitus interruptus but upregulates smoothend protein levels Drosophila melanogaster
2.7.7.50 metabolism the enzyme regulates Hedgehog pathway signaling activity depending on its capping-enzyme activity in the cytoplasm and through antagonizing protein kinase A Drosophila melanogaster