Literature summary extracted from

Buey, R.M.; Fernandez-Justel, D.; Marcos-Alcalde, I.; Winter, G.; Gomez-Puertas, P.; de Pereda, J.M.; Luis Revuelta, J.
A nucleotide-controlled conformational switch modulates the activity of eukaryotic IMP dehydrogenases (2017), Sci. Rep., 7, 2648 .

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
1.1.1.205	ATP	-	Eremothecium gossypii

Crystallization (Commentary)

EC Number	Crystallization (Comment)	Organism
1.1.1.205	enzyme in complex with ATP, vapor diffusion method, using 0.02 M D-glucose, 0.02 M D-mannose, 0.02 M D-galactose, 0.02 M L-sucrose, 0.02 M D-xylose,0.02 M N-acetyl-D-glucosamine, 0.05 M imidazole, 0.05 M MES, pH 6.5, 20% (w/v) glycerol, 20% (w/v) PEG-4000. Enzyme in complex with ATP/GDP, vapor diffusion method, using 0.1 M lithium acetate, 0.1 M Bis-Tris pH 6.0, 20% (w/v) Sokolan-CP42	Eremothecium gossypii

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.1.1.205	GDP	-	Eremothecium gossypii
1.1.1.205	GTP	-	Eremothecium gossypii

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1.1.1.205	IMP + NAD+ + H2O	Eremothecium gossypii	-	XMP + NADH + H+	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.1.1.205	Eremothecium gossypii	-	-	-

Purification (Commentary)

EC Number	Purification (Comment)	Organism
1.1.1.205	-	Eremothecium gossypii

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.1.1.205	IMP + NAD+ + H2O	-	Eremothecium gossypii	XMP + NADH + H+	-	?

Subunits

EC Number	Subunits	Comment	Organism
1.1.1.205	homotetramer	small angle X-ray scattering	Eremothecium gossypii

Synonyms

EC Number	Synonyms	Comment	Organism
1.1.1.205	IMPDH	-	Eremothecium gossypii
1.1.1.205	inosine-5'-monophosphate dehydrogenase	-	Eremothecium gossypii

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
1.1.1.205	NAD+	-	Eremothecium gossypii

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Release 2023.1 (January 2023)