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Literature summary extracted from

  • Ticak, T.; Kountz, D.J.; Girosky, K.E.; Krzycki, J.A.; Ferguson, D.J.
    A nonpyrrolysine member of the widely distributed trimethylamine methyltransferase family is a glycine betaine methyltransferase (2014), Proc. Natl. Acad. Sci. USA, 111, E4668-E4676 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.1.376 expressed in Escherichia coli BL21(DE3) cells Desulfitobacterium hafniense
2.1.1.378 expressed in Escherichia coli BL21(DE3) cells Desulfitobacterium hafniense

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.1.1.376 1.96
-
 glycine betaine at pH 6.5 and 37°C Desulfitobacterium hafniense

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.376 glycine betaine + a [Co(I) glycine betaine-specific corrinoid protein] Desulfitobacterium hafniense
-
 N,N-dimethylglycine + a [methyl-Co(III) glycine betaine-specific corrinoid protein]
-
 ?
2.1.1.376 glycine betaine + a [Co(I) glycine betaine-specific corrinoid protein] Desulfitobacterium hafniense Y51
-
 N,N-dimethylglycine + a [methyl-Co(III) glycine betaine-specific corrinoid protein]
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.376 Desulfitobacterium hafniense Q24SP7
-
-
2.1.1.376 Desulfitobacterium hafniense Y51 Q24SP7
-
-
2.1.1.378 Desulfitobacterium hafniense Q24SP6
-
-
2.1.1.378 Desulfitobacterium hafniense Y51 Q24SP6
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.1.378 nickel affinity column chromatography Desulfitobacterium hafniense

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.376 glycine betaine + a [Co(I) glycine betaine-specific corrinoid protein]
-
 Desulfitobacterium hafniense N,N-dimethylglycine + a [methyl-Co(III) glycine betaine-specific corrinoid protein]
-
 ?
2.1.1.376 glycine betaine + a [Co(I) glycine betaine-specific corrinoid protein]
-
 Desulfitobacterium hafniense Y51 N,N-dimethylglycine + a [methyl-Co(III) glycine betaine-specific corrinoid protein]
-
 ?
2.1.1.376 glycine betaine + cob(I)alamin
-
 Desulfitobacterium hafniense N,N-dimethylglycine + methyl-cob(III)alamin
-
 ?
2.1.1.376 glycine betaine + cob(I)alamin
-
 Desulfitobacterium hafniense Y51 N,N-dimethylglycine + methyl-cob(III)alamin
-
 ?
2.1.1.378 methyl-cob(III)alamin + tetrahydrofolate
-
 Desulfitobacterium hafniense cob(II)alamin + 5-methyltetrahydrofolate
-
 ?
2.1.1.378 methyl-cob(III)alamin + tetrahydrofolate
-
 Desulfitobacterium hafniense Y51 cob(II)alamin + 5-methyltetrahydrofolate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.376 DSY3156
-
 Desulfitobacterium hafniense
2.1.1.376 GB:corrinoid methyltransferase
-
 Desulfitobacterium hafniense
2.1.1.376 glycine betaine:corrinoid methyltransferase
-
 Desulfitobacterium hafniense
2.1.1.376 MtgB
-
 Desulfitobacterium hafniense
2.1.1.378 DSY3157
-
 Desulfitobacterium hafniense
2.1.1.378 methylCbl:THF methyltransferase
-
 Desulfitobacterium hafniense
2.1.1.378 methylcobalamin:tetrahydrofolate methyltransferase
-
 Desulfitobacterium hafniense
2.1.1.378 MtgA
-
 Desulfitobacterium hafniense