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Literature summary extracted from

  • Zhang, G.; Leclercq, S.O.; Tian, J.; Wang, C.; Yahara, K.; Ai, G.; Liu, S.; Feng, J.
    A new subclass of intrinsic aminoglycoside nucleotidyltransferases, ANT(3'')-II, is horizontally transferred among Acinetobacter spp. by homologous recombination (2017), PLoS Genet., 13, e1006602 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.7.47 expressed in Escherichia coli DH5alpha cells Acinetobacter baumannii
2.7.7.47 expressed in Escherichia coli DH5alpha cells Acinetobacter junii
2.7.7.47 expressed in Escherichia coli DH5alpha cells Acinetobacter gyllenbergii
2.7.7.47 expressed in Escherichia coli DH5alpha cells Acinetobacter sp. NIPH 758 (IIb)
2.7.7.47 expressed in Escherichia coli DH5alpha cells Acinetobacter ursingii
2.7.7.47 expressed in Escherichia coli DH5alpha cells Acinetobacter pittii
2.7.7.47 expressed in Escherichia coli DH5alpha cells Acinetobacter parvus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.47 ATP + spectinomycin Acinetobacter baumannii
-
 diphosphate + 9-adenylylspectinomycin
-
 ?
2.7.7.47 ATP + spectinomycin Acinetobacter junii
-
 diphosphate + 9-adenylylspectinomycin
-
 ?
2.7.7.47 ATP + spectinomycin Acinetobacter gyllenbergii
-
 diphosphate + 9-adenylylspectinomycin
-
 ?
2.7.7.47 ATP + spectinomycin Acinetobacter sp. NIPH 758 (IIb)
-
 diphosphate + 9-adenylylspectinomycin
-
 ?
2.7.7.47 ATP + spectinomycin Acinetobacter ursingii
-
 diphosphate + 9-adenylylspectinomycin
-
 ?
2.7.7.47 ATP + spectinomycin Acinetobacter pittii
-
 diphosphate + 9-adenylylspectinomycin
-
 ?
2.7.7.47 ATP + spectinomycin Acinetobacter parvus
-
 diphosphate + 9-adenylylspectinomycin
-
 ?
2.7.7.47 ATP + spectinomycin Acinetobacter pittii PHEA-2
-
 diphosphate + 9-adenylylspectinomycin
-
 ?
2.7.7.47 ATP + spectinomycin Acinetobacter parvus CIP 108168
-
 diphosphate + 9-adenylylspectinomycin
-
 ?
2.7.7.47 ATP + spectinomycin Acinetobacter pittii CIP 70.29
-
 diphosphate + 9-adenylylspectinomycin
-
 ?
2.7.7.47 ATP + spectinomycin Acinetobacter baumannii ATCC 17978
-
 diphosphate + 9-adenylylspectinomycin
-
 ?
2.7.7.47 ATP + spectinomycin Acinetobacter baumannii AYE
-
 diphosphate + 9-adenylylspectinomycin
-
 ?
2.7.7.47 ATP + spectinomycin Acinetobacter junii CIP 64.5
-
 diphosphate + 9-adenylylspectinomycin
-
 ?
2.7.7.47 ATP + spectinomycin Acinetobacter gyllenbergii NIPH 230
-
 diphosphate + 9-adenylylspectinomycin
-
 ?
2.7.7.47 ATP + spectinomycin Acinetobacter ursingii ANC 3649
-
 diphosphate + 9-adenylylspectinomycin
-
 ?
2.7.7.47 ATP + spectinomycin Acinetobacter baumannii ATCC 19606
-
 diphosphate + 9-adenylylspectinomycin
-
 ?
2.7.7.47 ATP + streptomycin Acinetobacter baumannii
-
 diphosphate + 3''-adenylylstreptomycin
-
 ?
2.7.7.47 ATP + streptomycin Acinetobacter junii
-
 diphosphate + 3''-adenylylstreptomycin
-
 ?
2.7.7.47 ATP + streptomycin Acinetobacter gyllenbergii
-
 diphosphate + 3''-adenylylstreptomycin
-
 ?
2.7.7.47 ATP + streptomycin Acinetobacter sp. NIPH 758 (IIb)
-
 diphosphate + 3''-adenylylstreptomycin
-
 ?
2.7.7.47 ATP + streptomycin Acinetobacter ursingii
-
 diphosphate + 3''-adenylylstreptomycin
-
 ?
2.7.7.47 ATP + streptomycin Acinetobacter pittii
-
 diphosphate + 3''-adenylylstreptomycin
-
 ?
2.7.7.47 ATP + streptomycin Acinetobacter parvus
-
 diphosphate + 3''-adenylylstreptomycin
-
 ?
2.7.7.47 ATP + streptomycin Acinetobacter pittii PHEA-2
-
 diphosphate + 3''-adenylylstreptomycin
-
 ?
2.7.7.47 ATP + streptomycin Acinetobacter parvus CIP 108168
-
 diphosphate + 3''-adenylylstreptomycin
-
 ?
2.7.7.47 ATP + streptomycin Acinetobacter pittii CIP 70.29
-
 diphosphate + 3''-adenylylstreptomycin
-
 ?
2.7.7.47 ATP + streptomycin Acinetobacter baumannii ATCC 17978
-
 diphosphate + 3''-adenylylstreptomycin
-
 ?
2.7.7.47 ATP + streptomycin Acinetobacter baumannii AYE
-
 diphosphate + 3''-adenylylstreptomycin
-
 ?
2.7.7.47 ATP + streptomycin Acinetobacter junii CIP 64.5
-
 diphosphate + 3''-adenylylstreptomycin
-
 ?
2.7.7.47 ATP + streptomycin Acinetobacter gyllenbergii NIPH 230
-
 diphosphate + 3''-adenylylstreptomycin
-
 ?
2.7.7.47 ATP + streptomycin Acinetobacter ursingii ANC 3649
-
 diphosphate + 3''-adenylylstreptomycin
-
 ?
2.7.7.47 ATP + streptomycin Acinetobacter baumannii ATCC 19606
-
 diphosphate + 3''-adenylylstreptomycin
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.47 Acinetobacter baumannii
-
-
-
2.7.7.47 Acinetobacter baumannii D0CEM6
-
-
2.7.7.47 Acinetobacter baumannii Q2FD58
-
-
2.7.7.47 Acinetobacter baumannii ATCC 17978 Q2FD58
-
-
2.7.7.47 Acinetobacter baumannii ATCC 19606 D0CEM6
-
-
2.7.7.47 Acinetobacter baumannii AYE
-
-
-
2.7.7.47 Acinetobacter gyllenbergii
-
-
-
2.7.7.47 Acinetobacter gyllenbergii NIPH 230
-
-
-
2.7.7.47 Acinetobacter junii
-
-
-
2.7.7.47 Acinetobacter junii CIP 64.5
-
-
-
2.7.7.47 Acinetobacter parvus
-
-
-
2.7.7.47 Acinetobacter parvus CIP 108168
-
-
-
2.7.7.47 Acinetobacter pittii
-
-
-
2.7.7.47 Acinetobacter pittii CIP 70.29
-
-
-
2.7.7.47 Acinetobacter pittii PHEA-2
-
-
-
2.7.7.47 Acinetobacter sp. NIPH 758 (IIb) N8W714
-
-
2.7.7.47 Acinetobacter ursingii
-
-
-
2.7.7.47 Acinetobacter ursingii ANC 3649
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.7.47 His-Bind protein column chromatography and Superdex 200 gel filtration Acinetobacter baumannii
2.7.7.47 His-Bind protein column chromatography and Superdex 200 gel filtration Acinetobacter junii
2.7.7.47 His-Bind protein column chromatography and Superdex 200 gel filtration Acinetobacter gyllenbergii
2.7.7.47 His-Bind protein column chromatography and Superdex 200 gel filtration Acinetobacter sp. NIPH 758 (IIb)
2.7.7.47 His-Bind protein column chromatography and Superdex 200 gel filtration Acinetobacter ursingii
2.7.7.47 His-Bind protein column chromatography and Superdex 200 gel filtration Acinetobacter pittii
2.7.7.47 His-Bind protein column chromatography and Superdex 200 gel filtration Acinetobacter parvus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.47 ATP + spectinomycin
-
 Acinetobacter baumannii diphosphate + 9-adenylylspectinomycin
-
 ?
2.7.7.47 ATP + spectinomycin
-
 Acinetobacter junii diphosphate + 9-adenylylspectinomycin
-
 ?
2.7.7.47 ATP + spectinomycin
-
 Acinetobacter gyllenbergii diphosphate + 9-adenylylspectinomycin
-
 ?
2.7.7.47 ATP + spectinomycin
-
 Acinetobacter sp. NIPH 758 (IIb) diphosphate + 9-adenylylspectinomycin
-
 ?
2.7.7.47 ATP + spectinomycin
-
 Acinetobacter ursingii diphosphate + 9-adenylylspectinomycin
-
 ?
2.7.7.47 ATP + spectinomycin
-
 Acinetobacter pittii diphosphate + 9-adenylylspectinomycin
-
 ?
2.7.7.47 ATP + spectinomycin
-
 Acinetobacter parvus diphosphate + 9-adenylylspectinomycin
-
 ?
2.7.7.47 ATP + spectinomycin
-
 Acinetobacter pittii PHEA-2 diphosphate + 9-adenylylspectinomycin
-
 ?
2.7.7.47 ATP + spectinomycin
-
 Acinetobacter parvus CIP 108168 diphosphate + 9-adenylylspectinomycin
-
 ?
2.7.7.47 ATP + spectinomycin
-
 Acinetobacter pittii CIP 70.29 diphosphate + 9-adenylylspectinomycin
-
 ?
2.7.7.47 ATP + spectinomycin
-
 Acinetobacter baumannii ATCC 17978 diphosphate + 9-adenylylspectinomycin
-
 ?
2.7.7.47 ATP + spectinomycin
-
 Acinetobacter baumannii AYE diphosphate + 9-adenylylspectinomycin
-
 ?
2.7.7.47 ATP + spectinomycin
-
 Acinetobacter junii CIP 64.5 diphosphate + 9-adenylylspectinomycin
-
 ?
2.7.7.47 ATP + spectinomycin
-
 Acinetobacter gyllenbergii NIPH 230 diphosphate + 9-adenylylspectinomycin
-
 ?
2.7.7.47 ATP + spectinomycin
-
 Acinetobacter ursingii ANC 3649 diphosphate + 9-adenylylspectinomycin
-
 ?
2.7.7.47 ATP + spectinomycin
-
 Acinetobacter baumannii ATCC 19606 diphosphate + 9-adenylylspectinomycin
-
 ?
2.7.7.47 ATP + streptomycin
-
 Acinetobacter baumannii diphosphate + 3''-adenylylstreptomycin
-
 ?
2.7.7.47 ATP + streptomycin
-
 Acinetobacter junii diphosphate + 3''-adenylylstreptomycin
-
 ?
2.7.7.47 ATP + streptomycin
-
 Acinetobacter gyllenbergii diphosphate + 3''-adenylylstreptomycin
-
 ?
2.7.7.47 ATP + streptomycin
-
 Acinetobacter sp. NIPH 758 (IIb) diphosphate + 3''-adenylylstreptomycin
-
 ?
2.7.7.47 ATP + streptomycin
-
 Acinetobacter ursingii diphosphate + 3''-adenylylstreptomycin
-
 ?
2.7.7.47 ATP + streptomycin
-
 Acinetobacter pittii diphosphate + 3''-adenylylstreptomycin
-
 ?
2.7.7.47 ATP + streptomycin
-
 Acinetobacter parvus diphosphate + 3''-adenylylstreptomycin
-
 ?
2.7.7.47 ATP + streptomycin
-
 Acinetobacter pittii PHEA-2 diphosphate + 3''-adenylylstreptomycin
-
 ?
2.7.7.47 ATP + streptomycin
-
 Acinetobacter parvus CIP 108168 diphosphate + 3''-adenylylstreptomycin
-
 ?
2.7.7.47 ATP + streptomycin
-
 Acinetobacter pittii CIP 70.29 diphosphate + 3''-adenylylstreptomycin
-
 ?
2.7.7.47 ATP + streptomycin
-
 Acinetobacter baumannii ATCC 17978 diphosphate + 3''-adenylylstreptomycin
-
 ?
2.7.7.47 ATP + streptomycin
-
 Acinetobacter baumannii AYE diphosphate + 3''-adenylylstreptomycin
-
 ?
2.7.7.47 ATP + streptomycin
-
 Acinetobacter junii CIP 64.5 diphosphate + 3''-adenylylstreptomycin
-
 ?
2.7.7.47 ATP + streptomycin
-
 Acinetobacter gyllenbergii NIPH 230 diphosphate + 3''-adenylylstreptomycin
-
 ?
2.7.7.47 ATP + streptomycin
-
 Acinetobacter ursingii ANC 3649 diphosphate + 3''-adenylylstreptomycin
-
 ?
2.7.7.47 ATP + streptomycin
-
 Acinetobacter baumannii ATCC 19606 diphosphate + 3''-adenylylstreptomycin
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.7.47 ANT(3'')-II
-
 Acinetobacter baumannii
2.7.7.47 ANT(3'')-II
-
 Acinetobacter junii
2.7.7.47 ANT(3'')-II
-
 Acinetobacter gyllenbergii
2.7.7.47 ANT(3'')-II
-
 Acinetobacter sp. NIPH 758 (IIb)
2.7.7.47 ANT(3'')-II
-
 Acinetobacter ursingii
2.7.7.47 ANT(3'')-II
-
 Acinetobacter pittii
2.7.7.47 ANT(3'')-II
-
 Acinetobacter parvus

General Information

EC Number General Information Comment Organism
2.7.7.47 malfunction enzyme inactivation decreases streptomycin and spectinomycin resistance by 16fold and 2fold, respectively Acinetobacter baumannii
2.7.7.47 physiological function the enzyme supports streptomycin and spectinomycin resistance Acinetobacter baumannii
2.7.7.47 physiological function the enzyme supports streptomycin and spectinomycin resistance Acinetobacter junii
2.7.7.47 physiological function the enzyme supports streptomycin and spectinomycin resistance Acinetobacter gyllenbergii
2.7.7.47 physiological function the enzyme supports streptomycin and spectinomycin resistance Acinetobacter sp. NIPH 758 (IIb)
2.7.7.47 physiological function the enzyme supports streptomycin and spectinomycin resistance Acinetobacter ursingii
2.7.7.47 physiological function the enzyme supports streptomycin and spectinomycin resistance Acinetobacter pittii
2.7.7.47 physiological function the enzyme supports streptomycin and spectinomycin resistance Acinetobacter parvus