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Literature summary extracted from

  • Zhao, Y.; Jiang, H.; Gu, M.; Zu, C.; Zheng, X.
    Gemcitabine resistance in triple-negative breast cancer cells can be reverted by Drosophila melanogaster deoxyribonucleoside kinase in the nucleus or cytosol (2020), Oncol. Lett., 20, 247 .
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.7.1.145 medicine the enzyme is a potential candidate for reversing acquired gemcitabine resistance in triplex1enegative breast cancer cells, which may form the basis of strategies for the treatment of patients with drugx1eresistant triplex1enegative breast cancer Drosophila melanogaster

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.145 expressed in MDA-MB-231 and MDA-MB-231R cells Drosophila melanogaster

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.145 ATP + a 2'-deoxyribonucleoside Drosophila melanogaster
-
 ADP + a 2'-deoxyribonucleoside 5'-phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.145 Drosophila melanogaster
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.145 ATP + a 2'-deoxyribonucleoside
-
 Drosophila melanogaster ADP + a 2'-deoxyribonucleoside 5'-phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.145 deoxyribonucleoside kinase
-
 Drosophila melanogaster
2.7.1.145 dNK
-
 Drosophila melanogaster