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Literature summary extracted from

  • Beretta, S.; Gritti, L.; Verpelli, C.; Sala, C.
    Eukaryotic elongation factor 2 kinase a pharmacological target to regulate protein translation dysfunction in neurological diseases (2020), Neuroscience, 445, 42-49 .
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.20 Calmodulin
-
 Mus musculus

Application

EC Number Application Comment Organism
2.7.11.20 medicine the enzyme is a valuable target in treating epilepsy, depression and major neurodegenerative diseases Mus musculus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.20 Ca2+ dependent on Mus musculus
2.7.11.20 Zn2+ a Zn2+ ion is required for activity Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.20 ATP + [eukaryotic elongation factor 2] Mus musculus the enzyme phosphorylates Thr56 of eukaryotic elongation factor 2 ADP + [eukaryotic elongation factor 2] phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.20 Mus musculus O08796
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.20 hippocampus
-
 Mus musculus
-
2.7.11.20 neuron
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.20 ATP + [eukaryotic elongation factor 2] the enzyme phosphorylates Thr56 of eukaryotic elongation factor 2 Mus musculus ADP + [eukaryotic elongation factor 2] phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.20 eEF2 kinase
-
 Mus musculus
2.7.11.20 eEF2K
-
 Mus musculus
2.7.11.20 eukaryotic elongation factor 2 kinase
-
 Mus musculus

General Information

EC Number General Information Comment Organism
2.7.11.20 malfunction enzyme deficiency leads to impaired mGluR-long term potentiation, higher miniature inhibitory postsynaptic current frequency and amplitude in hippocampal granule cells, higher tonic inhibition measured in the in granule cells of the dentate gyrus, and impaired AMPAR-endocytosis following mGluR activation. The heterozygous deletion of the enzyme in mice models of Alzheimer's disease rescue cognitive, morphological and electrophysiological alterations associated to Alzheimer's disease Mus musculus