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Literature summary extracted from

  • Vences-Guzman, M.A.; Paula Goetting-Minesky, M.; Guan, Z.; Castillo-Ramirez, S.; Cordoba-Castro, L.A.; Lopez-Lara, I.M.; Geiger, O.; Sohlenkamp, C.; Christopher Fenno, J.
    1,2-Diacylglycerol choline phosphotransferase catalyzes the final step in the unique Treponema denticola phosphatidylcholine biosynthesis pathway (2017), Mol. Microbiol., 103, 896-912 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.8.2 expression in Escherichia coli Treponema denticola

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.8.2 EDTA complete inhibition Treponema denticola

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.8.2 Co2+ about 50% of the activity with Mn2+ Treponema denticola
2.7.8.2 Mg2+ about 10% of the activity with Mn2+ Treponema denticola
2.7.8.2 Mn2+ required for full activity Treponema denticola
2.7.8.2 additional information no substitute for Mn2+: Ca2+, Cu2+, Ni2+ Treponema denticola

Organism

EC Number Organism UniProt Comment Textmining
2.7.8.2 Treponema denticola Q73RR4
-
-
2.7.8.2 Treponema denticola DSM 14222 Q73RR4
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.8.2 CDP-choline + 1,2-diacyl-sn-glycerol
-
 Treponema denticola CMP + a phosphatidylcholine
-
 ?
2.7.8.2 CDP-choline + 1,2-diacyl-sn-glycerol
-
 Treponema denticola DSM 14222 CMP + a phosphatidylcholine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.8.2 CPT
-
 Treponema denticola
2.7.8.2 TDE0021
-
 Treponema denticola

General Information

EC Number General Information Comment Organism
2.7.8.2 physiological function expression of Cpt complements a Saccharomyces cerevisiae CPT1 mutant, and expression of the entire Treponema denticola LicCA-Cpt pathway in Escherichia coli results in phosphatidylcholine biosynthesis Treponema denticola