EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.146 | (2S)-2-[[(E)-[(1,3-benzothiazol-2-yl)imino](methylsulfanyl)methyl]amino]-3-(4-hydroxyphenyl)propanoic acid | - |
Rattus norvegicus | |
1.1.1.146 | (E)-5-((benzo[d]thiazol-2-ylimino)(methylthio)methylamino)-2-hydroxybenzoic acid | - |
Rattus norvegicus | |
1.1.1.146 | 2-hydroxy-5-[[(E)-[(5-methoxy-1,3-benzothiazol-2-yl)imino](methylsulfanyl)methyl]amino]benzoic acid | - |
Rattus norvegicus | |
1.1.1.146 | 2-hydroxy-5-[[(E)-[(5-methyl-1,3-benzothiazol-2-yl)imino](methylsulfanyl)methyl]amino]benzoic acid | - |
Rattus norvegicus | |
1.1.1.146 | 2-hydroxy-5-[[(E)-[(6-methoxy-1,3-benzothiazol-2-yl)imino](methylsulfanyl)methyl]amino]benzoic acid | - |
Rattus norvegicus | |
1.1.1.146 | 2-hydroxy-5-[[(E)-[(6-methyl-1,3-benzothiazol-2-yl)imino](methylsulfanyl)methyl]amino]benzoic acid | - |
Rattus norvegicus | |
1.1.1.146 | 2-hydroxy-5-[[(E)-[(7-methoxy-1,3-benzothiazol-2-yl)imino](methylsulfanyl)methyl]amino]benzoic acid | - |
Rattus norvegicus | |
1.1.1.146 | 2-hydroxy-5-[[(E)-[(7-methyl-1,3-benzothiazol-2-yl)imino](methylsulfanyl)methyl]amino]benzoic acid | - |
Rattus norvegicus | |
1.1.1.146 | 5-[[(E)-[(5-chloro-1,3-benzothiazol-2-yl)imino](methylsulfanyl)methyl]amino]-2-hydroxybenzoic acid | - |
Rattus norvegicus | |
1.1.1.146 | 5-[[(E)-[(5-ethoxy-1,3-benzothiazol-2-yl)imino](methylsulfanyl)methyl]amino]-2-hydroxybenzoic acid | - |
Rattus norvegicus | |
1.1.1.146 | 5-[[(E)-[(5-fluoro-1,3-benzothiazol-2-yl)imino](methylsulfanyl)methyl]amino]-2-hydroxybenzoic acid | - |
Rattus norvegicus | |
1.1.1.146 | 5-[[(E)-[(6-chloro-1,3-benzothiazol-2-yl)imino](methylsulfanyl)methyl]amino]-2-hydroxybenzoic acid | - |
Rattus norvegicus | |
1.1.1.146 | 5-[[(E)-[(6-ethoxy-1,3-benzothiazol-2-yl)imino](methylsulfanyl)methyl]amino]-2-hydroxybenzoic acid | - |
Rattus norvegicus | |
1.1.1.146 | 5-[[(E)-[(6-fluoro-1,3-benzothiazol-2-yl)imino](methylsulfanyl)methyl]amino]-2-hydroxybenzoic acid | - |
Rattus norvegicus | |
1.1.1.146 | 5-[[(E)-[(7-chloro-1,3-benzothiazol-2-yl)imino](methylsulfanyl)methyl]amino]-2-hydroxybenzoic acid | - |
Rattus norvegicus | |
1.1.1.146 | 5-[[(E)-[(7-ethoxy-1,3-benzothiazol-2-yl)imino](methylsulfanyl)methyl]amino]-2-hydroxybenzoic acid | - |
Rattus norvegicus | |
1.1.1.146 | 5-[[(E)-[(7-fluoro-1,3-benzothiazol-2-yl)imino](methylsulfanyl)methyl]amino]-2-hydroxybenzoic acid | - |
Rattus norvegicus | |
1.1.1.146 | carbenoxolone | - |
Rattus norvegicus | |
1.1.1.146 | clobenzorex | - |
Rattus norvegicus | |
1.1.1.146 | PF-877423 | - |
Rattus norvegicus | |
1.1.1.146 | resveratrol | - |
Rattus norvegicus | |
1.1.1.146 | SAR184841 | - |
Rattus norvegicus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.1.1.146 | 0.193 | - |
cortisone | at pH 7.5 and 37°C | Rattus norvegicus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.146 | corticosterone + NADPH + H+ | Rattus norvegicus | - |
corticosterol + NADP+ | - |
? | |
1.1.1.146 | cortisone + NADPH + H+ | Rattus norvegicus | - |
cortisol + NADP+ | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.1.1.146 | Rattus norvegicus | P16232 | - |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.1.1.146 | white adipose tissue | - |
Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.146 | corticosterone + NADPH + H+ | - |
Rattus norvegicus | corticosterol + NADP+ | - |
? | |
1.1.1.146 | cortisone + NADPH + H+ | - |
Rattus norvegicus | cortisol + NADP+ | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.1.1.146 | 11-beta hydroxysteroid dehydrogenase type 1 | - |
Rattus norvegicus |
1.1.1.146 | 11beta-HSD1 | - |
Rattus norvegicus |
1.1.1.146 | 11beta-hydroxysteroid dehydrogenase type 1 | - |
Rattus norvegicus |
EC Number | General Information | Comment | Organism |
---|---|---|---|
1.1.1.146 | malfunction | the inhibition of isoform 11beta-HSD1 attenuates the development of type 2 diabetes mellitus, insulin resistance, metabolic syndrome and other diseases mediated by excessive cortisol production | Rattus norvegicus |