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Literature summary extracted from

  • Boese, C.J.; Nye, J.; Buster, D.W.; McLamarrah, T.A.; Byrnes, A.E.; Slep, K.C.; Rusan, N.M.; Rogers, G.C.
    Asterless is a polo-like kinase 4 substrate that both activates and inhibits kinase activity depending on its phosphorylation state (2018), Mol. Biol. Cell, 29, 2874-2886 .
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.21 Asterless-A-13A phospho-null Asterless-A (13A) stimulates kinase activity by relieving L1-mediated isoform Plk4 autoinhibition Drosophila melanogaster

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.21 Asterless-A-13PM phosphomimetic Asterless-A (13PM) inhibits isoform Plk4 activity by autophosphorylation of isoform Plk4 s kinase domain Drosophila melanogaster

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.21 Drosophila melanogaster O97143
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.21 S2 cell
-
 Drosophila melanogaster
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.21 ATP + Asterless protein isoform Plk4 phosphorylates the N-terminal domain of Asterless protein Drosophila melanogaster ADP + phosphorylated Asterless protein
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.11.21 ? x * 125000, GST-tagged enzyme, SDS-PAGE Drosophila melanogaster

Synonyms

EC Number Synonyms Comment Organism
2.7.11.21 PLK4
-
 Drosophila melanogaster
2.7.11.21 polo-like kinase 4
-
 Drosophila melanogaster