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Literature summary extracted from

  • Bao, J.; Wu, Y.; Wang, L.; Zhu, Y.
    The role of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 in esophageal squamous cell carcinoma (2020), Medicine (Baltimore), 99, e19626 .
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.7.1.105 medicine high PFKFB3 protein and gene expression may be associated with the occurrence, development, and prognosis of esophageal squamous cell carcinoma Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.105 ATP + beta-D-fructose 6-phosphate Homo sapiens
-
 ADP + beta-D-fructose 2,6-bisphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.105 Homo sapiens Q16875
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.105 esophageal squamous cell carcinoma cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.105 ATP + beta-D-fructose 6-phosphate
-
 Homo sapiens ADP + beta-D-fructose 2,6-bisphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.105 6-phosphofructo kinase-2/fructose diphosphatase-2 isoenzyme 3
-
 Homo sapiens
2.7.1.105 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3
-
 Homo sapiens
2.7.1.105 PFKFB3
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
2.7.1.105 Homo sapiens enzyme expression in esophageal squamous cell carcinoma cell is significantly higher than in adjacent non-tumor tissues up