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Literature summary extracted from

  • Balabin, F.A.; Sveshnikova, A.N.
    Computational biology analysis of platelet signaling reveals roles of feedbacks through phospholipase C and inositol 1,4,5-trisphosphate 3-kinase in controlling amplitude and duration of calcium oscillations (2016), Mathr. Biosci., 276, 67-74 .
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.127 cytosol
-
 Homo sapiens 5829
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.127 Mg2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.127 ATP + 1D-myo-inositol 1,4,5-trisphosphate Homo sapiens
-
 ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.127 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.127 blood platelet
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.127 ATP + 1D-myo-inositol 1,4,5-trisphosphate
-
 Homo sapiens ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.127 inositol 1,4,5-trisphosphate 3-kinase
-
 Homo sapiens
2.7.1.127 IP3K
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.127 ATP
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.7.1.127 metabolism main mechanisms of platelet calcium signaling implemented in the model. The model includes two main compartments: cytosol and dense tubular system (DTS). Thrombin binding to PAR1 receptor leads to phospholipase C (PLC) activation and inositol-3-phosphate (IP3) release into cytosol. IP3 binding to its receptors (IP3R) in the DTS membrane opens this channels for release of calcium that is normally contained in the DTS because of the SERCA pump action. Cytosolic IP3 is being phosphorylated by inositol triphosphate-kinase (IP3K) into IP4 that might be included in the phosphoinositide turnover. Two feedback loops: a PLC-dependent positive feedback loop and the IP3K-dependent negative loop. System modeling, overview Homo sapiens
2.7.1.127 physiological function analysis of the roles of feedbacks through phospholipase C and inositol 1,4,5-trisphosphate 3-kinase (IP3K) by means of a computer model of calcium signal transduction in platelets Homo sapiens