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Literature summary extracted from

  • Bhattacharya, S.; McElhanon, K.E.; Gushchina, L.V.; Weisleder, N.
    Role of phosphatidylinositol-4,5-bisphosphate 3-kinase signaling in vesicular trafficking (2016), Life Sci., 167, 39-45 .
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.153 Insulin
-
 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.153 Wortmannin a PI3K inhibitor Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.153 lysosome
-
 Homo sapiens 5764
-
2.7.1.153 vesicle
-
 Homo sapiens 31982
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.153 Mg2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.153 ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate Homo sapiens
-
 ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.153 Homo sapiens P42336 AND P42338 AND P48736 AND O00329 subunits PIK3CA/p110alpha, PIK3CB/p110beta, PIK3CG/p110gamma, and PIK3CD/p110delta
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.153 hepatocyte
-
 Homo sapiens
-
2.7.1.153 pancreas
-
 Homo sapiens
-
2.7.1.153 pancreatic beta cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.153 ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 Homo sapiens ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.153 phosphatidylinositol-4,5-bisphosphate 3-kinase
-
 Homo sapiens
2.7.1.153 PIK3
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.153 ATP
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.7.1.153 malfunction treatment of cells with the PI3K inhibitor wortmannin, significantly attenuates GLUT4 exocytosis. Cellular deficiency of insulin signaling machineries dampens the expression of the insulin signaling proteins and obliterates downstream signaling mediated through the PI3K pathway Homo sapiens
2.7.1.153 metabolism analysis of the PI3K signaling cascade, overview Homo sapiens
2.7.1.153 physiological function phosphatidylinositol-4,5-bisphosphate 3-kinases (PI3Ks) are regulatory enzymes involved in the generation of lipid species that modulate cellular signaling pathways through downstream effectors to influence a variety of cellular functions. Stimulation of PI3K can enhance lysosomal trafficking events to the plasma membrane. Insulin-induced activation of PI3K alters glucose transporter GLUT4 recycling, positive regulatory role for PI3K pathway in the GLUT4 receptor recycling process. PI3K demonstrates both positive and negative regulation of insulin release. The p110gamma subunit of type I PI3K is required to maintain a ready pool of insulin loaded vesicles for the recruitment of insulin granules in the islet beta-cells for release upon exocytic stimulation. PI3K C2alpha, a class II PI3K isoform, exerts signaling effects on insulin secretion from pancreatic beta-cells by promoting insulin loaded granules in insulinoma cells. PI3K is also known to contribute to glucose homeostasis by regulating beta-cell gene expression Homo sapiens